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- NCIT_C513 IAO_0000115 "A congener of the antimetabolite fluorouracil with antineoplastic activity. Tegafur is a prodrug that is gradually converted to fluorouracil in the liver by the cytochrome P-450 enzyme. Subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by inhibiting thymidylate synthase and reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate. (NCI04)" @default.
- NCIT_C513 NCIT_A32 NCIT_C1909 @default.
- NCIT_C513 NCIT_NHC0 "C513" @default.
- NCIT_C513 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C513 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C513 NCIT_P108 "Tegafur" @default.
- NCIT_C513 NCIT_P175 "148958" @default.
- NCIT_C513 NCIT_P207 "C0016778" @default.
- NCIT_C513 NCIT_P210 "17902-23-7" @default.
- NCIT_C513 NCIT_P319 "1548R74NSZ" @default.
- NCIT_C513 NCIT_P322 "FDA" @default.
- NCIT_C513 NCIT_P322 "GDC" @default.
- NCIT_C513 NCIT_P325 "An anticancer drug that belongs to the family of drugs called antimetabolites." @default.
- NCIT_C513 NCIT_P329 "39248" @default.
- NCIT_C513 NCIT_P330 "39248" @default.
- NCIT_C513 NCIT_P350 "C8H9FN2O3" @default.
- NCIT_C513 NCIT_P366 "Tegafur" @default.
- NCIT_C513 NCIT_P375 "Tegafur" @default.
- NCIT_C513 NCIT_P399 "39248" @default.
- NCIT_C513 normalizedInformationContent "86.239998175184226" @default.
- NCIT_C513 referenceCount "8" @default.
- NCIT_C513 hasExactSynonym "5-Fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione" @default.
- NCIT_C513 hasExactSynonym "5-Fluoro-1-(tetrahydro-2-furanyl)-2,4-(1H,3H)-pyrimidinedione" @default.
- NCIT_C513 hasExactSynonym "5-Fluoro-1-(tetrahydro-2-furyl)-uracil" @default.
- NCIT_C513 hasExactSynonym "Citofur" @default.
- NCIT_C513 hasExactSynonym "Coparogin" @default.
- NCIT_C513 hasExactSynonym "Exonal" @default.
- NCIT_C513 hasExactSynonym "FT" @default.
- NCIT_C513 hasExactSynonym "FT-207" @default.
- NCIT_C513 hasExactSynonym "Fental" @default.
- NCIT_C513 hasExactSynonym "Florafur" @default.
- NCIT_C513 hasExactSynonym "Fluorofur" @default.
- NCIT_C513 hasExactSynonym "Ftorafur" @default.
- NCIT_C513 hasExactSynonym "Ftoral" @default.
- NCIT_C513 hasExactSynonym "Ftoralon" @default.
- NCIT_C513 hasExactSynonym "Fulaid" @default.
- NCIT_C513 hasExactSynonym "Fulfeel" @default.
- NCIT_C513 hasExactSynonym "Furafluor" @default.
- NCIT_C513 hasExactSynonym "Furofutran" @default.
- NCIT_C513 hasExactSynonym "Futraful" @default.
- NCIT_C513 hasExactSynonym "Lamar" @default.
- NCIT_C513 hasExactSynonym "Lifril" @default.
- NCIT_C513 hasExactSynonym "MJF-12264" @default.
- NCIT_C513 hasExactSynonym "N1-(2'-Furanidyl)-5-fluorouracil" @default.
- NCIT_C513 hasExactSynonym "Neberk" @default.
- NCIT_C513 hasExactSynonym "Nitobanil" @default.
- NCIT_C513 hasExactSynonym "Riol" @default.
- NCIT_C513 hasExactSynonym "Sinoflurol" @default.
- NCIT_C513 hasExactSynonym "Sunfural" @default.
- NCIT_C513 hasExactSynonym "TEGAFUR" @default.
- NCIT_C513 hasExactSynonym "Tefsiel" @default.
- NCIT_C513 hasExactSynonym "Tegafur" @default.
- NCIT_C513 hasExactSynonym "Uracil, 5-fluoro-1-(tetrahydro-2-furyl)-" @default.
- NCIT_C513 hasExactSynonym "Utefos" @default.
- NCIT_C513 hasExactSynonym "WR-220066" @default.
- NCIT_C513 hasExactSynonym "tegafur" @default.
- NCIT_C513 inSubset NCIT_C128784 @default.
- NCIT_C513 inSubset NCIT_C157711 @default.
- NCIT_C513 inSubset NCIT_C157712 @default.
- NCIT_C513 inSubset NCIT_C176424 @default.
- NCIT_C513 inSubset NCIT_C177537 @default.
- NCIT_C513 inSubset NCIT_C63923 @default.
- NCIT_C513 type Class @default.
- NCIT_C513 isDefinedBy ncit.owl @default.
- NCIT_C513 label "Tegafur" @default.
- NCIT_C513 subClassOf NCIT_C1557 @default.
- NCIT_C513 subClassOf NCIT_C186664 @default.
- NCIT_C513 subClassOf NCIT_C1908 @default.
- NCIT_C513 subClassOf NCIT_C1909 @default.
- NCIT_C513 subClassOf NCIT_C2021 @default.
- NCIT_C513 subClassOf NCIT_C272 @default.
- NCIT_C513 subClassOf NCIT_C274 @default.
- NCIT_C513 subClassOf NCIT_C471 @default.
- NCIT_C513 subClassOf NCIT_C513 @default.