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- NCIT_C52174 IAO_0000115 "A cruciferous vegetable extract with potential chemopreventive activities. Broccoli sprout extract contains a high amount of sulforaphane, a naturally occurring isothiocyanate. Sulforaphane activates the transcription factor NF-E2-related factor 2 (Nrf2), a member of the basic leucine zipper family, which binds to and activates antioxidant-response elements (AREs). Subsequently, activated AREs mediate the transcription of antioxidant enzymes (particularly glutathione-S-transferase and quinone oxidoreductase), resulting in the detoxification of highly reactive carcinogens. AREs are cis-acting regulatory enhancer elements found in the 5' flanking region of many phase II detoxification enzymes." @default.
- NCIT_C52174 NCIT_NHC0 "C52174" @default.
- NCIT_C52174 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C52174 NCIT_P107 "Broccoli Sprout Extract" @default.
- NCIT_C52174 NCIT_P108 "Broccoli Sprout Extract" @default.
- NCIT_C52174 NCIT_P207 "C1707048" @default.
- NCIT_C52174 NCIT_P319 "128UH9LOAE" @default.
- NCIT_C52174 NCIT_P322 "CTRP" @default.
- NCIT_C52174 NCIT_P322 "FDA" @default.
- NCIT_C52174 NCIT_P325 "A substance being studied in the prevention of cancer. Broccoli sprout extract comes from newly sprouted broccoli. It causes cells to make enzymes that may protect them against cancer-causing toxins in the body, and it may also block the growth of cancer cells." @default.
- NCIT_C52174 NCIT_P329 "455271" @default.
- NCIT_C52174 NCIT_P330 "455271" @default.
- NCIT_C52174 NCIT_P366 "Broccoli_Sprout_Extract" @default.
- NCIT_C52174 NCIT_P399 "455271" @default.
- NCIT_C52174 normalizedInformationContent "100" @default.
- NCIT_C52174 referenceCount "1" @default.
- NCIT_C52174 hasExactSynonym "BROCCOLI SPROUT" @default.
- NCIT_C52174 hasExactSynonym "Broccoli Sprout Extract" @default.
- NCIT_C52174 hasExactSynonym "broccoli sprout extract" @default.
- NCIT_C52174 inSubset NCIT_C116977 @default.
- NCIT_C52174 inSubset NCIT_C116978 @default.
- NCIT_C52174 inSubset NCIT_C176424 @default.
- NCIT_C52174 inSubset NCIT_C63923 @default.
- NCIT_C52174 type Class @default.
- NCIT_C52174 isDefinedBy ncit.owl @default.
- NCIT_C52174 label "Broccoli Sprout Extract" @default.
- NCIT_C52174 subClassOf NCIT_C106104 @default.
- NCIT_C52174 subClassOf NCIT_C106105 @default.
- NCIT_C52174 subClassOf NCIT_C1892 @default.
- NCIT_C52174 subClassOf NCIT_C1908 @default.
- NCIT_C52174 subClassOf NCIT_C1909 @default.
- NCIT_C52174 subClassOf NCIT_C52174 @default.
- NCIT_C52174 subClassOf NCIT_C66892 @default.