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- NCIT_C52183 IAO_0000115 "A recombinant protein with megakaryopoiesis stimulating activity. Romiplostim mimics endogenous thrombopoietin (TPO), directly binding to and activating the platelet thrombopoietin receptor (TpoR, Mpl, or CD110 antigen), a cytokine receptor belonging to the hematopoietin receptor superfamily. Activation of TpoR stimulates the proliferation and differentiation of megakaryocytes, resulting in an increase in the production of blood platelets." @default.
- NCIT_C52183 NCIT_A7 NCIT_C17695 @default.
- NCIT_C52183 NCIT_NHC0 "C52183" @default.
- NCIT_C52183 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C52183 NCIT_P107 "Romiplostim" @default.
- NCIT_C52183 NCIT_P108 "Romiplostim" @default.
- NCIT_C52183 NCIT_P207 "C2364481" @default.
- NCIT_C52183 NCIT_P210 "267639-76-9" @default.
- NCIT_C52183 NCIT_P302 "chronic immune thrombocytopenic purpura" @default.
- NCIT_C52183 NCIT_P319 "GN5XU2DXKV" @default.
- NCIT_C52183 NCIT_P322 "CTRP" @default.
- NCIT_C52183 NCIT_P322 "FDA" @default.
- NCIT_C52183 NCIT_P325 "A drug used to treat patients with immune thrombocytopenic purpura (ITP) who do not get better with other forms of treatment. In ITP, platelets (cells that cause blood clots to form) are destroyed by the immune system. Romiplostim is being studied as a way to treat low platelet counts caused by chemotherapy. It binds to the thrombopoietin receptor and causes the bone marrow to make more platelets. Romiplostim is also being studied in the treatment of myelodysplastic syndromes (a group of diseases in which the bone marrow does not make enough healthy blood cells). It is a type of thrombopoietin agonist." @default.
- NCIT_C52183 NCIT_P329 "459753" @default.
- NCIT_C52183 NCIT_P330 "459753" @default.
- NCIT_C52183 NCIT_P366 "AMG531" @default.
- NCIT_C52183 NCIT_P399 "459753" @default.
- NCIT_C52183 normalizedInformationContent "100" @default.
- NCIT_C52183 referenceCount "1" @default.
- NCIT_C52183 hasExactSynonym "AMG 531" @default.
- NCIT_C52183 hasExactSynonym "Amgen Megakaryopoiesis Protein 2" @default.
- NCIT_C52183 hasExactSynonym "Nplate" @default.
- NCIT_C52183 hasExactSynonym "ROMIPLOSTIM" @default.
- NCIT_C52183 hasExactSynonym "Romiplostim" @default.
- NCIT_C52183 hasExactSynonym "romiplostim" @default.
- NCIT_C52183 inSubset NCIT_C116977 @default.
- NCIT_C52183 inSubset NCIT_C116978 @default.
- NCIT_C52183 inSubset NCIT_C176424 @default.
- NCIT_C52183 inSubset NCIT_C63923 @default.
- NCIT_C52183 type Class @default.
- NCIT_C52183 isDefinedBy ncit.owl @default.
- NCIT_C52183 label "Romiplostim" @default.
- NCIT_C52183 subClassOf NCIT_C1283 @default.
- NCIT_C52183 subClassOf NCIT_C1908 @default.
- NCIT_C52183 subClassOf NCIT_C1909 @default.
- NCIT_C52183 subClassOf NCIT_C2395 @default.
- NCIT_C52183 subClassOf NCIT_C307 @default.
- NCIT_C52183 subClassOf NCIT_C308 @default.
- NCIT_C52183 subClassOf NCIT_C387 @default.
- NCIT_C52183 subClassOf NCIT_C52183 @default.
- NCIT_C52183 subClassOf NCIT_C530 @default.