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- NCIT_C52196 IAO_0000115 "An epoxomicin derivate with potential antineoplastic activity. Carfilzomib irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S catalytic core subunit of the proteasome, a protease complex responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth." @default.
- NCIT_C52196 NCIT_A32 NCIT_C1909 @default.
- NCIT_C52196 NCIT_A7 NCIT_C13737 @default.
- NCIT_C52196 NCIT_NHC0 "C52196" @default.
- NCIT_C52196 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C52196 NCIT_P107 "Carfilzomib" @default.
- NCIT_C52196 NCIT_P108 "Carfilzomib" @default.
- NCIT_C52196 NCIT_P207 "C1709429" @default.
- NCIT_C52196 NCIT_P210 "868540-17-4" @default.
- NCIT_C52196 NCIT_P302 "relapsed multiple myeloma (MM)" @default.
- NCIT_C52196 NCIT_P319 "72X6E3J5AR" @default.
- NCIT_C52196 NCIT_P322 "CTRP" @default.
- NCIT_C52196 NCIT_P322 "FDA" @default.
- NCIT_C52196 NCIT_P322 "GDC" @default.
- NCIT_C52196 NCIT_P329 "459751" @default.
- NCIT_C52196 NCIT_P330 "459751" @default.
- NCIT_C52196 NCIT_P350 "C40H57N5O7" @default.
- NCIT_C52196 NCIT_P366 "PR-171" @default.
- NCIT_C52196 NCIT_P375 "Carfilzomib" @default.
- NCIT_C52196 NCIT_P399 "459751" @default.
- NCIT_C52196 normalizedInformationContent "81.653330900245635" @default.
- NCIT_C52196 referenceCount "16" @default.
- NCIT_C52196 hasExactSynonym "(2S)-N-((1S)-1-Benzyl-2-(((1S)-3-methyl-1-(((2R)-2-methyloxiran-2-yl)carbonyl)butyl)amino)-2-oxoethyl)-4-methyl-2-(((2S)-2-((morpholin-4-ylacetyl)amino)-4-phenylbutanoyl)amino)pentanamide" @default.
- NCIT_C52196 hasExactSynonym "CARFILZOMIB" @default.
- NCIT_C52196 hasExactSynonym "CFZ" @default.
- NCIT_C52196 hasExactSynonym "Carfilnat" @default.
- NCIT_C52196 hasExactSynonym "Carfilzomib" @default.
- NCIT_C52196 hasExactSynonym "Kyprolis" @default.
- NCIT_C52196 hasExactSynonym "PR-171" @default.
- NCIT_C52196 inSubset NCIT_C116977 @default.
- NCIT_C52196 inSubset NCIT_C116978 @default.
- NCIT_C52196 inSubset NCIT_C128784 @default.
- NCIT_C52196 inSubset NCIT_C157711 @default.
- NCIT_C52196 inSubset NCIT_C157712 @default.
- NCIT_C52196 inSubset NCIT_C176424 @default.
- NCIT_C52196 inSubset NCIT_C177537 @default.
- NCIT_C52196 inSubset NCIT_C63923 @default.
- NCIT_C52196 type Class @default.
- NCIT_C52196 isDefinedBy ncit.owl @default.
- NCIT_C52196 label "Carfilzomib" @default.
- NCIT_C52196 subClassOf NCIT_C163758 @default.
- NCIT_C52196 subClassOf NCIT_C1908 @default.
- NCIT_C52196 subClassOf NCIT_C1909 @default.
- NCIT_C52196 subClassOf NCIT_C2160 @default.
- NCIT_C52196 subClassOf NCIT_C274 @default.
- NCIT_C52196 subClassOf NCIT_C471 @default.
- NCIT_C52196 subClassOf NCIT_C52196 @default.