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- NCIT_C52200 IAO_0000115 "An orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Cabozantinib strongly binds to and inhibits several RTKs, which are often overexpressed in a variety of cancer cell types, including hepatocyte growth factor receptor (MET), RET (rearranged during transfection), vascular endothelial growth factor receptor types 1 (VEGFR-1), 2 (VEGFR-2), and 3 (VEGFR-3), mast/stem cell growth factor (KIT), FMS-like tyrosine kinase 3 (FLT-3), TIE-2 (TEK tyrosine kinase, endothelial), tropomyosin-related kinase B (TRKB) and AXL. This may result in an inhibition of both tumor growth and angiogenesis, and eventually lead to tumor regression." @default.
- NCIT_C52200 NCIT_A32 NCIT_C1909 @default.
- NCIT_C52200 NCIT_A5 NCIT_C97938 @default.
- NCIT_C52200 NCIT_A7 NCIT_C17328 @default.
- NCIT_C52200 NCIT_A7 NCIT_C17475 @default.
- NCIT_C52200 NCIT_A7 NCIT_C17975 @default.
- NCIT_C52200 NCIT_A7 NCIT_C18186 @default.
- NCIT_C52200 NCIT_A7 NCIT_C18488 @default.
- NCIT_C52200 NCIT_A7 NCIT_C18539 @default.
- NCIT_C52200 NCIT_A7 NCIT_C26202 @default.
- NCIT_C52200 NCIT_A7 NCIT_C26203 @default.
- NCIT_C52200 NCIT_A7 NCIT_C28496 @default.
- NCIT_C52200 NCIT_A7 NCIT_C33983 @default.
- NCIT_C52200 NCIT_NHC0 "C52200" @default.
- NCIT_C52200 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C52200 NCIT_P107 "Cabozantinib" @default.
- NCIT_C52200 NCIT_P108 "Cabozantinib" @default.
- NCIT_C52200 NCIT_P207 "C3181682" @default.
- NCIT_C52200 NCIT_P210 "849217-68-1" @default.
- NCIT_C52200 NCIT_P319 "1C39JW444G" @default.
- NCIT_C52200 NCIT_P322 "CTRP" @default.
- NCIT_C52200 NCIT_P322 "FDA" @default.
- NCIT_C52200 NCIT_P322 "GDC" @default.
- NCIT_C52200 NCIT_P322 "PCDC" @default.
- NCIT_C52200 NCIT_P350 "C28H24FN3O5" @default.
- NCIT_C52200 NCIT_P366 "XL184" @default.
- NCIT_C52200 NCIT_P375 "Cabozantinib" @default.
- NCIT_C52200 normalizedInformationContent "100" @default.
- NCIT_C52200 referenceCount "1" @default.
- NCIT_C52200 hasExactSynonym "1,1-Cyclopropanedicarboxamide, N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4- fluorophenyl)-" @default.
- NCIT_C52200 hasExactSynonym "CABOZANTINIB" @default.
- NCIT_C52200 hasExactSynonym "Cabozantinib" @default.
- NCIT_C52200 hasExactSynonym "N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1- dicarboxamide" @default.
- NCIT_C52200 inSubset NCIT_C116977 @default.
- NCIT_C52200 inSubset NCIT_C116978 @default.
- NCIT_C52200 inSubset NCIT_C128784 @default.
- NCIT_C52200 inSubset NCIT_C157711 @default.
- NCIT_C52200 inSubset NCIT_C157712 @default.
- NCIT_C52200 inSubset NCIT_C177537 @default.
- NCIT_C52200 inSubset NCIT_C179478 @default.
- NCIT_C52200 inSubset NCIT_C179531 @default.
- NCIT_C52200 inSubset NCIT_C63923 @default.
- NCIT_C52200 type Class @default.
- NCIT_C52200 isDefinedBy ncit.owl @default.
- NCIT_C52200 label "Cabozantinib" @default.
- NCIT_C52200 subClassOf NCIT_C129824 @default.
- NCIT_C52200 subClassOf NCIT_C129825 @default.
- NCIT_C52200 subClassOf NCIT_C1404 @default.
- NCIT_C52200 subClassOf NCIT_C143099 @default.
- NCIT_C52200 subClassOf NCIT_C159438 @default.
- NCIT_C52200 subClassOf NCIT_C163758 @default.
- NCIT_C52200 subClassOf NCIT_C163953 @default.
- NCIT_C52200 subClassOf NCIT_C164000 @default.
- NCIT_C52200 subClassOf NCIT_C1742 @default.
- NCIT_C52200 subClassOf NCIT_C1908 @default.
- NCIT_C52200 subClassOf NCIT_C1909 @default.
- NCIT_C52200 subClassOf NCIT_C1967 @default.
- NCIT_C52200 subClassOf NCIT_C200418 @default.
- NCIT_C52200 subClassOf NCIT_C2189 @default.
- NCIT_C52200 subClassOf NCIT_C274 @default.
- NCIT_C52200 subClassOf NCIT_C471 @default.
- NCIT_C52200 subClassOf NCIT_C52200 @default.
- NCIT_C52200 subClassOf NCIT_C93259 @default.