Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C52275> ?p ?o ?g. }
- NCIT_C52275 IAO_0000115 "Human ABCC1 wild-type allele is located in the vicinity of 16p13.1 and is approximately 193 kb in length. This allele, which encodes multidrug resistance-associated protein 1, is involved in multispecific organic anion transport." @default.
- NCIT_C52275 NCIT_NHC0 "C52275" @default.
- NCIT_C52275 NCIT_P100 "158343" @default.
- NCIT_C52275 NCIT_P102 "NM_004996" @default.
- NCIT_C52275 NCIT_P106 "Gene or Genome" @default.
- NCIT_C52275 NCIT_P107 "ABCC1 wt Allele" @default.
- NCIT_C52275 NCIT_P108 "ABCC1 wt Allele" @default.
- NCIT_C52275 NCIT_P207 "C1704873" @default.
- NCIT_C52275 NCIT_P211 "ATP binding" @default.
- NCIT_C52275 NCIT_P211 "ATP-binding cassette (ABC) transporter activity" @default.
- NCIT_C52275 NCIT_P211 "drug resistance" @default.
- NCIT_C52275 NCIT_P211 "integral to plasma membrane" @default.
- NCIT_C52275 NCIT_P211 "membrane fraction" @default.
- NCIT_C52275 NCIT_P211 "transport" @default.
- NCIT_C52275 NCIT_P211 "transporter activity" @default.
- NCIT_C52275 NCIT_P321 "4363" @default.
- NCIT_C52275 NCIT_P322 "CTRP" @default.
- NCIT_C52275 NCIT_P366 "ABCC1_wt_Allele" @default.
- NCIT_C52275 NCIT_P96 "Multiple Drug Resistance-Associated Protein" @default.
- NCIT_C52275 NCIT_P98 "Expressed in lung, testis, and peripheral blood mononuclear cells, the 200 kb human MRP1 Gene (ABC family) at 16p13.1 - telomeric to MYH11 - contains thirty-one exons that encode a plasma membrane drug-efflux transporter associated with multidrug resistance. A 7.8-8.2 kb mRNA is transcribed and several variant transcripts maintain the open reading frame. MRP1 contains a high proportion of class 0 introns. Conservation of intron/exon organization and sequence suggest that MRP-related transporters evolved by fusion from a shared common ancestor with CFTR and MDR1 encoding polytopic membrane proteins. MRP1 also appears to regulate LTC4 transport, which promotes chemotaxis to CCL19 and dendritic cell migration to lymph nodes. MRP1 is over expressed in a multidrug-resistant SCLC cell line." @default.
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- NCIT_C52275 normalizedInformationContent "100" @default.
- NCIT_C52275 referenceCount "1" @default.
- NCIT_C52275 hasExactSynonym "ABC29" @default.
- NCIT_C52275 hasExactSynonym "ABCC" @default.
- NCIT_C52275 hasExactSynonym "ABCC1 wt Allele" @default.
- NCIT_C52275 hasExactSynonym "ABCC1" @default.
- NCIT_C52275 hasExactSynonym "ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 wt Allele" @default.
- NCIT_C52275 hasExactSynonym "ATP-Binding Cassette, Subfamily C, Member 1 Gene" @default.
- NCIT_C52275 hasExactSynonym "GS-X" @default.
- NCIT_C52275 hasExactSynonym "MRP" @default.
- NCIT_C52275 hasExactSynonym "MRP1" @default.
- NCIT_C52275 inSubset NCIT_C116977 @default.
- NCIT_C52275 inSubset NCIT_C142799 @default.
- NCIT_C52275 inSubset NCIT_C142800 @default.
- NCIT_C52275 type Class @default.
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- NCIT_C52275 label "ABCC1 wt Allele" @default.
- NCIT_C52275 subClassOf NCIT_C158414 @default.
- NCIT_C52275 subClassOf NCIT_C16612 @default.
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