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- NCIT_C52361 IAO_0000115 "Human CYP2D6 wild-type allele is located in the vicinity of 22q13.1 and is approximately 4 kb in length. This allele, which encodes cytochrome P450 2D6 protein, plays a role in the metabolism of drugs and xenobiotics. The CYP2D6 gene is highly polymorphic in the human population. Many allelic variants of this gene contribute to the poor metabolizer phenotype. Conversely, two variant alleles of this gene contribute to the rapid metabolizer phenotype. Individuals who are poor metabolizers of cytochrome P450 2D6 substrates are at increased risk for the development of pesticide-induced somatic Parkinson's disease." @default.
- NCIT_C52361 NCIT_NHC0 "C52361" @default.
- NCIT_C52361 NCIT_P100 "124030" @default.
- NCIT_C52361 NCIT_P102 "NM_000106" @default.
- NCIT_C52361 NCIT_P106 "Gene or Genome" @default.
- NCIT_C52361 NCIT_P107 "CYP2D6 wt Allele" @default.
- NCIT_C52361 NCIT_P108 "CYP2D6 wt Allele" @default.
- NCIT_C52361 NCIT_P207 "C1705120" @default.
- NCIT_C52361 NCIT_P321 "1565" @default.
- NCIT_C52361 NCIT_P322 "CTRP" @default.
- NCIT_C52361 NCIT_P366 "CYP2D6_wt_Allele" @default.
- NCIT_C52361 NCIT_P96 "Cytochrome P450 2D6" @default.
- NCIT_C52361 NCIT_P98 "The poor metabolizer phenotype is characterized by the inability to use cytochrome P450-dependent metabolic pathways for drug elimination. The rapid metabolizer phenotype is characterized by the enhanced ability to use cytochrome P450-dependent metabolic pathways for drug elimination." @default.
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- NCIT_C52361 NCIT_R41 NCIT_C79740 @default.
- NCIT_C52361 normalizedInformationContent "100" @default.
- NCIT_C52361 referenceCount "1" @default.
- NCIT_C52361 hasExactSynonym "CPD6" @default.
- NCIT_C52361 hasExactSynonym "CYP2D" @default.
- NCIT_C52361 hasExactSynonym "CYP2D6 wt Allele" @default.
- NCIT_C52361 hasExactSynonym "CYP2DL1" @default.
- NCIT_C52361 hasExactSynonym "Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 wt Allele" @default.
- NCIT_C52361 hasExactSynonym "P450-DB1" @default.
- NCIT_C52361 hasExactSynonym "P450C2D" @default.
- NCIT_C52361 inSubset NCIT_C116977 @default.
- NCIT_C52361 inSubset NCIT_C142799 @default.
- NCIT_C52361 inSubset NCIT_C142800 @default.
- NCIT_C52361 type Class @default.
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- NCIT_C52361 label "CYP2D6 wt Allele" @default.
- NCIT_C52361 subClassOf NCIT_C16612 @default.
- NCIT_C52361 subClassOf NCIT_C21281 @default.
- NCIT_C52361 subClassOf NCIT_C25939 @default.
- NCIT_C52361 subClassOf NCIT_C26511 @default.
- NCIT_C52361 subClassOf NCIT_C26517 @default.
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- NCIT_C52361 equivalentClass B77d974755632dba5aa2a4c2172f9dc3f @default.