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- NCIT_C526 IAO_0000115 "A pentacyclic triterpenoid aglycone metabolite of glycyrrhizin, which is a product of the plant Glycyrrhiza glabra (licorice), with potential expectorant, and gastrokinetic activities. After administration, enoxolone inhibits the metabolism of prostaglandins by both 15-hydroxyprostaglandin dehydrogenase [NAD(+)] and prostaglandin reductase 2. Therefore, this agent potentiates the activity of prostaglandin E2 and F2alpha, which inhibits gastric secretion while stimulating pancreatic secretion and the secretion of intestinal and respiratory mucus, leading to increased intestinal motility and antitussive effects. Additionally, this agent inhibits 11 beta-hydroxysteroid dehydrogenase and other enzymes involved in the conversion of cortisol to cortisone in the kidneys." @default.
- NCIT_C526 NCIT_NHC0 "C526" @default.
- NCIT_C526 NCIT_P106 "Organic Chemical" @default.
- NCIT_C526 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C526 NCIT_P108 "Enoxolone" @default.
- NCIT_C526 NCIT_P175 "35347" @default.
- NCIT_C526 NCIT_P207 "C0017986" @default.
- NCIT_C526 NCIT_P210 "15301-63-0" @default.
- NCIT_C526 NCIT_P210 "471-53-4" @default.
- NCIT_C526 NCIT_P319 "P540XA09DR" @default.
- NCIT_C526 NCIT_P322 "FDA" @default.
- NCIT_C526 NCIT_P350 "C30H46O4" @default.
- NCIT_C526 NCIT_P366 "Glycyrrhetic_Acid" @default.
- NCIT_C526 NCIT_P368 "CHEBI:30853" @default.
- NCIT_C526 normalizedInformationContent "100" @default.
- NCIT_C526 referenceCount "1" @default.
- NCIT_C526 hasExactSynonym "(3beta,20beta)-3-Hydroxy-11-oxoolean-12-en-29-oic Acid" @default.
- NCIT_C526 hasExactSynonym "18-beta-Glycyrrhetinic Acid" @default.
- NCIT_C526 hasExactSynonym "3-beta-Hydroxy-11-oxoolean-12-en-30-oic acid" @default.
- NCIT_C526 hasExactSynonym "ENOXOLONE" @default.
- NCIT_C526 hasExactSynonym "Enoxolone" @default.
- NCIT_C526 hasExactSynonym "Glycyrrhetic Acid" @default.
- NCIT_C526 hasExactSynonym "Glycyrrhetic acid" @default.
- NCIT_C526 hasExactSynonym "Glycyrrhetinic Acid" @default.
- NCIT_C526 hasExactSynonym "Glycyrrhetinic acid" @default.
- NCIT_C526 hasExactSynonym "beta-Glycyrrhetinic Acid" @default.
- NCIT_C526 inSubset NCIT_C63923 @default.
- NCIT_C526 type Class @default.
- NCIT_C526 isDefinedBy ncit.owl @default.
- NCIT_C526 label "Enoxolone" @default.
- NCIT_C526 subClassOf NCIT_C1908 @default.
- NCIT_C526 subClassOf NCIT_C1909 @default.
- NCIT_C526 subClassOf NCIT_C471 @default.
- NCIT_C526 subClassOf NCIT_C526 @default.
- NCIT_C526 subClassOf NCIT_C54678 @default.