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- NCIT_C52955 IAO_0000115 "Human GTF2B wild-type allele is located within 1p22-p21 and is approximately 39 kb in length. This allele, which encodes transcription initiation factor IIB protein, is involved in transcription through the modulation of the formation of the RNA polymerase II preinitiation complex." @default.
- NCIT_C52955 NCIT_NHC0 "C52955" @default.
- NCIT_C52955 NCIT_P100 "189963" @default.
- NCIT_C52955 NCIT_P102 "NM_001514" @default.
- NCIT_C52955 NCIT_P106 "Gene or Genome" @default.
- NCIT_C52955 NCIT_P108 "GTF2B wt Allele" @default.
- NCIT_C52955 NCIT_P207 "C1705406" @default.
- NCIT_C52955 NCIT_P211 "general RNA polymerase II transcription factor activity" @default.
- NCIT_C52955 NCIT_P211 "transcription from Pol II promoter" @default.
- NCIT_C52955 NCIT_P321 "2959" @default.
- NCIT_C52955 NCIT_P366 "GTF2B_wt_Allele" @default.
- NCIT_C52955 NCIT_P96 "General Transcription Factor TFIIB" @default.
- NCIT_C52955 NCIT_P98 "The GTF2B (TFIIB) gene encodes a protein that is a general transcription factor and plays a central role in preinitiation complex assembly. TFIIB is one of the ubiquitous factors required for transcription initiation by RNA polymerase II. TFIIB localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. TFIIB provides a bridge between promoter-bound TFIID and RNA Polymerase II. TFIIB possesses sequence-specific DNA-binding ability and interacts with the TFIIB-recognition element (BRE), present in many promoters. BRE suppresses the basal level of transcription elicited by a core promoter, which increases the amplitude of transcriptional stimulation in the presence of an activator where an activator can disrupt the TFIIB-BRE interaction within a promoter-bound complex. The TFIIB gene is located at chromosome 1p22-p21 on the short arm of chromosome 1. (from PMID 11711430, LocusLink 2959)" @default.
- NCIT_C52955 NCIT_R130 NCIT_C19779 @default.
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- NCIT_C52955 NCIT_R130 NCIT_C39109 @default.
- NCIT_C52955 NCIT_R130 NCIT_C39216 @default.
- NCIT_C52955 NCIT_R145 NCIT_C12219 @default.
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- NCIT_C52955 NCIT_R145 NCIT_C64389 @default.
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- NCIT_C52955 NCIT_R37 NCIT_C18597 @default.
- NCIT_C52955 NCIT_R37 NCIT_C19077 @default.
- NCIT_C52955 NCIT_R37 NCIT_C19986 @default.
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- NCIT_C52955 NCIT_R37 NCIT_C21050 @default.
- NCIT_C52955 NCIT_R37 NCIT_C28498 @default.
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- NCIT_C52955 NCIT_R40 NCIT_C13432 @default.
- NCIT_C52955 NCIT_R40 NCIT_C13446 @default.
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- NCIT_C52955 NCIT_R40 NCIT_C14135 @default.
- NCIT_C52955 NCIT_R40 NCIT_C32221 @default.
- NCIT_C52955 NCIT_R40 NCIT_C34070 @default.
- NCIT_C52955 NCIT_R41 NCIT_C14182 @default.
- NCIT_C52955 NCIT_R41 NCIT_C14225 @default.
- NCIT_C52955 NCIT_R41 NCIT_C14234 @default.
- NCIT_C52955 NCIT_R41 NCIT_C14250 @default.
- NCIT_C52955 NCIT_R41 NCIT_C14262 @default.
- NCIT_C52955 NCIT_R41 NCIT_C14282 @default.
- NCIT_C52955 NCIT_R41 NCIT_C25796 @default.
- NCIT_C52955 NCIT_R41 NCIT_C79740 @default.
- NCIT_C52955 normalizedInformationContent "100" @default.
- NCIT_C52955 referenceCount "1" @default.
- NCIT_C52955 hasExactSynonym "GTF2B wt Allele" @default.
- NCIT_C52955 hasExactSynonym "GTF2B" @default.
- NCIT_C52955 hasExactSynonym "General Transcription Factor IIB wt Allele" @default.
- NCIT_C52955 hasExactSynonym "RNA Polymerase II Transcription Factor IIB Gene" @default.
- NCIT_C52955 hasExactSynonym "TF2B Gene" @default.
- NCIT_C52955 hasExactSynonym "TFIIB Gene" @default.
- NCIT_C52955 hasExactSynonym "Transcription Factor IIB Gene" @default.
- NCIT_C52955 type Class @default.
- NCIT_C52955 isDefinedBy ncit.owl @default.
- NCIT_C52955 label "GTF2B wt Allele" @default.
- NCIT_C52955 subClassOf NCIT_C16612 @default.
- NCIT_C52955 subClassOf NCIT_C20420 @default.
- NCIT_C52955 subClassOf NCIT_C20648 @default.
- NCIT_C52955 subClassOf NCIT_C30096 @default.
- NCIT_C52955 subClassOf NCIT_C52955 @default.
- NCIT_C52955 subClassOf NCIT_C54362 @default.
- NCIT_C52955 equivalentClass Ba6c60013f03b7ad7759f650d17e56958 @default.
- NCIT_C52955 equivalentClass Bc4d9785f5c1a15b1aa3314ed94ddc844 @default.