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- NCIT_C53137 IAO_0000115 "The sulfate salt form of codeine, a naturally occurring phenanthrene alkaloid and opioid agonist with analgesic, antidiarrheal and antitussive activity. Codeine sulfate mimics the actions of opioids by binding to the opioid receptors at many sites within the central nervous system (CNS). Stimulation of the mu-subtype opioid receptor stimulates the exchange of GTP for GDP on the G-protein complex and subsequently inhibits adenylate cyclase. This results in a decrease in intracellular cAMP and leads to a reduction in the release of neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline. The analgesic effect of codeine sulfate is likely due to its metabolite morphine, which induces opening of G-protein-coupled inwardly rectifying potassium (GIRK) channels and blocks the opening of N-type voltage-gated calcium channels, thereby resulting in hyperpolarization and reduced neuronal excitability." @default.
- NCIT_C53137 NCIT_A6 NCIT_C383 @default.
- NCIT_C53137 NCIT_NHC0 "C53137" @default.
- NCIT_C53137 NCIT_P106 "Organic Chemical" @default.
- NCIT_C53137 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C53137 NCIT_P108 "Codeine Sulfate" @default.
- NCIT_C53137 NCIT_P207 "C0304352" @default.
- NCIT_C53137 NCIT_P210 "6854-40-6" @default.
- NCIT_C53137 NCIT_P319 "11QV9BS0CB" @default.
- NCIT_C53137 NCIT_P322 "FDA" @default.
- NCIT_C53137 NCIT_P350 "2C18H21NO3.3H2O.H2SO4" @default.
- NCIT_C53137 NCIT_P366 "Codeine_Sulfate" @default.
- NCIT_C53137 normalizedInformationContent "100" @default.
- NCIT_C53137 referenceCount "1" @default.
- NCIT_C53137 hasExactSynonym "7,8-Didehydro-4,5-epoxy- 3-methoxy-17-methyl-(5a,6a)-Morphinan-6-ol Sulfate (2:1)" @default.
- NCIT_C53137 hasExactSynonym "CODEINE SULFATE" @default.
- NCIT_C53137 hasExactSynonym "Codeine Sulfate" @default.
- NCIT_C53137 hasExactSynonym "Codeine, sulfate" @default.
- NCIT_C53137 inSubset NCIT_C63923 @default.
- NCIT_C53137 type Class @default.
- NCIT_C53137 isDefinedBy ncit.owl @default.
- NCIT_C53137 label "Codeine Sulfate" @default.
- NCIT_C53137 subClassOf NCIT_C1506 @default.
- NCIT_C53137 subClassOf NCIT_C1657 @default.
- NCIT_C53137 subClassOf NCIT_C1908 @default.
- NCIT_C53137 subClassOf NCIT_C1909 @default.
- NCIT_C53137 subClassOf NCIT_C1913 @default.
- NCIT_C53137 subClassOf NCIT_C1916 @default.
- NCIT_C53137 subClassOf NCIT_C221 @default.
- NCIT_C53137 subClassOf NCIT_C53137 @default.
- NCIT_C53137 subClassOf NCIT_C67413 @default.
- NCIT_C53137 subClassOf NCIT_C718 @default.
- NCIT_C53137 subClassOf NCIT_C78272 @default.