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- NCIT_C54629 IAO_0000115 "Any natural or synthetic substance that inhibits the activity of any phase I metabolic enzyme. The cytochrome P450 (CYP450) mono-oxygenase family of enzymes catalyzes the majority of the phase I reactions. CYP450 enzymes oxidize xenobiotics, especially drugs and carcinogens, as well as certain endogenous substances. This leads to the introduction of a polar functional group to the compound, enhances their water solubility and renal excretion. However, a highly reactive intermediate and more toxic metabolite than the parent molecule may be produced that can potentially react with and damage DNA. The main CYP450 enzymes involved in the activation of carcinogens include CYP1A1, -1A2, -2A6, -2E1 and -3A4. Phase I enzymes inhibitors prevent the biotransformation of many pro-carcinogens to activated mutagens and carcinogens." @default.
- NCIT_C54629 NCIT_NHC0 "C54629" @default.
- NCIT_C54629 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C54629 NCIT_P108 "Phase I Enzymes Inhibitor" @default.
- NCIT_C54629 NCIT_P207 "C1882359" @default.
- NCIT_C54629 NCIT_P366 "Phase_I_Enzymes_Inhibitor" @default.
- NCIT_C54629 normalizedInformationContent "90.826665450122817" @default.
- NCIT_C54629 referenceCount "4" @default.
- NCIT_C54629 hasExactSynonym "Phase I Enzymes Inhibitor" @default.
- NCIT_C54629 type Class @default.
- NCIT_C54629 isDefinedBy ncit.owl @default.
- NCIT_C54629 label "Phase I Enzymes Inhibitor" @default.
- NCIT_C54629 subClassOf NCIT_C1892 @default.
- NCIT_C54629 subClassOf NCIT_C1908 @default.
- NCIT_C54629 subClassOf NCIT_C1909 @default.
- NCIT_C54629 subClassOf NCIT_C54629 @default.