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- NCIT_C557 IAO_0000115 "A 4-aminoquinoline with immunosuppressive, antiautophagy, and antimalarial activities. Although the precise mechanism of action is unknown, hydroxychloroquine may suppress immune function by interfering with the processing and presentation of antigens and the production of cytokines. As a lysosomotropic agent, hydroxychloroquine raises intralysosomal pH, impairing autophagic protein degradation; hydroxychloroquine-mediated accumulation of ineffective autophagosomes may result in cell death in tumor cells reliant on autophagy for survival. In addition, this agent is highly active against the erythrocytic forms of P. vivax and malariae and most strains of P. falciparum but not the gametocytes of P. falciparum." @default.
- NCIT_C557 NCIT_A32 NCIT_C1909 @default.
- NCIT_C557 NCIT_A5 NCIT_C29101 @default.
- NCIT_C557 NCIT_NHC0 "C557" @default.
- NCIT_C557 NCIT_P106 "Organic Chemical" @default.
- NCIT_C557 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C557 NCIT_P107 "Hydroxychloroquine" @default.
- NCIT_C557 NCIT_P108 "Hydroxychloroquine" @default.
- NCIT_C557 NCIT_P207 "C0020336" @default.
- NCIT_C557 NCIT_P210 "118-42-3" @default.
- NCIT_C557 NCIT_P302 "Malaria; Rheumatoid arthritis" @default.
- NCIT_C557 NCIT_P319 "4QWG6N8QKH" @default.
- NCIT_C557 NCIT_P322 "CTRP" @default.
- NCIT_C557 NCIT_P322 "FDA" @default.
- NCIT_C557 NCIT_P322 "GDC" @default.
- NCIT_C557 NCIT_P325 "A substance that decreases immune responses in the body. It is used to treat some autoimmune diseases, and is being studied as a treatment for graft-versus-host disease. Hydroxychloroquine belongs to the family of drugs called antiprotozoals." @default.
- NCIT_C557 NCIT_P329 "38571" @default.
- NCIT_C557 NCIT_P330 "38571" @default.
- NCIT_C557 NCIT_P350 "C18H26ClN3O" @default.
- NCIT_C557 NCIT_P366 "Hydroxychloroquine" @default.
- NCIT_C557 NCIT_P375 "Hydroxychloroquine" @default.
- NCIT_C557 NCIT_P399 "38571" @default.
- NCIT_C557 normalizedInformationContent "92.730304365937428" @default.
- NCIT_C557 referenceCount "3" @default.
- NCIT_C557 hasExactSynonym "HYDROXYCHLOROQUINE" @default.
- NCIT_C557 hasExactSynonym "Hydroxychloroquine" @default.
- NCIT_C557 hasExactSynonym "hydroxychloroquine" @default.
- NCIT_C557 inSubset NCIT_C116977 @default.
- NCIT_C557 inSubset NCIT_C116978 @default.
- NCIT_C557 inSubset NCIT_C128784 @default.
- NCIT_C557 inSubset NCIT_C157711 @default.
- NCIT_C557 inSubset NCIT_C157712 @default.
- NCIT_C557 inSubset NCIT_C173381 @default.
- NCIT_C557 inSubset NCIT_C173383 @default.
- NCIT_C557 inSubset NCIT_C176424 @default.
- NCIT_C557 inSubset NCIT_C177537 @default.
- NCIT_C557 inSubset NCIT_C63923 @default.
- NCIT_C557 type Class @default.
- NCIT_C557 isDefinedBy ncit.owl @default.
- NCIT_C557 label "Hydroxychloroquine" @default.
- NCIT_C557 subClassOf NCIT_C1908 @default.
- NCIT_C557 subClassOf NCIT_C1909 @default.
- NCIT_C557 subClassOf NCIT_C254 @default.
- NCIT_C557 subClassOf NCIT_C271 @default.
- NCIT_C557 subClassOf NCIT_C276 @default.
- NCIT_C557 subClassOf NCIT_C277 @default.
- NCIT_C557 subClassOf NCIT_C557 @default.