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- NCIT_C570 IAO_0000115 "A broad-spectrum, semi-synthetic beta-lactam carbapenem derived from thienamycin, produced by Streptomyces cattleya. Imipenem binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes that are involved in the last stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. This inactivation results in the weakening of the bacterial cell wall and eventually causes cell lysis. Imipenem has the greatest affinity for PBP 1A, 1B, and 2, and its lethal effect is related to binding to PBP 2 and 1B. This antibiotic is active against a wide range of gram-positive and gram-negative organisms and is stable in the presence of beta-lactamases. (NCI05)" @default.
- NCIT_C570 NCIT_NHC0 "C570" @default.
- NCIT_C570 NCIT_P106 "Antibiotic" @default.
- NCIT_C570 NCIT_P106 "Organic Chemical" @default.
- NCIT_C570 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C570 NCIT_P108 "Imipenem" @default.
- NCIT_C570 NCIT_P207 "C0020933" @default.
- NCIT_C570 NCIT_P210 "74431-23-5" @default.
- NCIT_C570 NCIT_P319 "71OTZ9ZE0A" @default.
- NCIT_C570 NCIT_P322 "FDA" @default.
- NCIT_C570 NCIT_P325 "An antibiotic drug used to treat severe or very resistant infection. It belongs to the family of drugs called carbapenems." @default.
- NCIT_C570 NCIT_P329 "42116" @default.
- NCIT_C570 NCIT_P330 "42116" @default.
- NCIT_C570 NCIT_P350 "C12H17N3O4S.H2O" @default.
- NCIT_C570 NCIT_P366 "Imipenem" @default.
- NCIT_C570 NCIT_P368 "CHEBI:51799" @default.
- NCIT_C570 NCIT_P399 "42116" @default.
- NCIT_C570 normalizedInformationContent "100" @default.
- NCIT_C570 referenceCount "1" @default.
- NCIT_C570 hasExactSynonym "1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic Acid, 6-(1-Hydroxyethyl)-3-((2-((iminomethyl)amino)ethyl)thio)-7-oxo-, Monohydrate, (5R-(5alpha,6alpha(R*)))-" @default.
- NCIT_C570 hasExactSynonym "IMIPENEM" @default.
- NCIT_C570 hasExactSynonym "Imipemide" @default.
- NCIT_C570 hasExactSynonym "Imipenem" @default.
- NCIT_C570 hasExactSynonym "MK-0787" @default.
- NCIT_C570 hasExactSynonym "imipenem" @default.
- NCIT_C570 inSubset NCIT_C176424 @default.
- NCIT_C570 inSubset NCIT_C63923 @default.
- NCIT_C570 type Class @default.
- NCIT_C570 isDefinedBy ncit.owl @default.
- NCIT_C570 label "Imipenem" @default.
- NCIT_C570 subClassOf NCIT_C1908 @default.
- NCIT_C570 subClassOf NCIT_C1909 @default.
- NCIT_C570 subClassOf NCIT_C254 @default.
- NCIT_C570 subClassOf NCIT_C258 @default.
- NCIT_C570 subClassOf NCIT_C260 @default.
- NCIT_C570 subClassOf NCIT_C570 @default.