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- NCIT_C576 IAO_0000115 "A synthetic nonsteroidal indole derivative with anti-inflammatory activity and chemopreventive properties. As a nonsteroidal anti-inflammatory drug (NSAID), indomethacin inhibits the enzyme cyclooxygenase, thereby preventing cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines. This agent also may inhibit the expression of multidrug-resistant protein type 1, resulting in increased efficacies of some antineoplastic agents in treating multi-drug resistant tumors. In addition, indomethacin activates phosphatases that inhibit the migration and proliferation of cancer cells and downregulates survivin, which may result in tumor cell apoptosis. (NCI04)" @default.
- NCIT_C576 NCIT_A32 NCIT_C1909 @default.
- NCIT_C576 NCIT_A5 NCIT_C47999 @default.
- NCIT_C576 NCIT_A7 NCIT_C17984 @default.
- NCIT_C576 NCIT_A7 NCIT_C19705 @default.
- NCIT_C576 NCIT_NHC0 "C576" @default.
- NCIT_C576 NCIT_P106 "Organic Chemical" @default.
- NCIT_C576 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C576 NCIT_P107 "Indomethacin" @default.
- NCIT_C576 NCIT_P108 "Indomethacin" @default.
- NCIT_C576 NCIT_P175 "77541" @default.
- NCIT_C576 NCIT_P207 "C0021246" @default.
- NCIT_C576 NCIT_P210 "53-86-1" @default.
- NCIT_C576 NCIT_P302 "Dysmennorhea; Inflammatory disorders; Pain" @default.
- NCIT_C576 NCIT_P319 "XXE1CET956" @default.
- NCIT_C576 NCIT_P322 "CTRP" @default.
- NCIT_C576 NCIT_P322 "FDA" @default.
- NCIT_C576 NCIT_P322 "GDC" @default.
- NCIT_C576 NCIT_P325 "A drug that reduces pain, fever, swelling, and redness. It is also being used to reduce tumor-induced suppression of the immune system and to increase the effectiveness of anticancer drugs. It is a type of nonsteroidal anti-inflammatory drug (NSAID)." @default.
- NCIT_C576 NCIT_P329 "39489" @default.
- NCIT_C576 NCIT_P330 "39489" @default.
- NCIT_C576 NCIT_P350 "C19H16ClNO4" @default.
- NCIT_C576 NCIT_P366 "Indomethacin" @default.
- NCIT_C576 NCIT_P368 "CHEBI:49662" @default.
- NCIT_C576 NCIT_P375 "Indomethacin" @default.
- NCIT_C576 NCIT_P399 "39489" @default.
- NCIT_C576 NCIT_R122 NCIT_C16484 @default.
- NCIT_C576 NCIT_R122 NCIT_C16486 @default.
- NCIT_C576 NCIT_R122 NCIT_C16554 @default.
- NCIT_C576 NCIT_R122 NCIT_C16865 @default.
- NCIT_C576 NCIT_R122 NCIT_C16946 @default.
- NCIT_C576 NCIT_R122 NCIT_C17021 @default.
- NCIT_C576 NCIT_R122 NCIT_C20027 @default.
- NCIT_C576 NCIT_R122 NCIT_C25948 @default.
- NCIT_C576 NCIT_R122 NCIT_C26548 @default.
- NCIT_C576 NCIT_R122 NCIT_C28459 @default.
- NCIT_C576 normalizedInformationContent "86.239998175184226" @default.
- NCIT_C576 referenceCount "8" @default.
- NCIT_C576 hasExactSynonym "1-(4-chlorobenzoyl)-5-methoxy- 2-methyl-1-H-indole-3-acetic acid" @default.
- NCIT_C576 hasExactSynonym "INDOMETHACIN" @default.
- NCIT_C576 hasExactSynonym "Indocin" @default.
- NCIT_C576 hasExactSynonym "Indometacin" @default.
- NCIT_C576 hasExactSynonym "Indomethacin" @default.
- NCIT_C576 hasExactSynonym "indomethacin" @default.
- NCIT_C576 inSubset NCIT_C116977 @default.
- NCIT_C576 inSubset NCIT_C116978 @default.
- NCIT_C576 inSubset NCIT_C128784 @default.
- NCIT_C576 inSubset NCIT_C157711 @default.
- NCIT_C576 inSubset NCIT_C157712 @default.
- NCIT_C576 inSubset NCIT_C173381 @default.
- NCIT_C576 inSubset NCIT_C173383 @default.
- NCIT_C576 inSubset NCIT_C176424 @default.
- NCIT_C576 inSubset NCIT_C177537 @default.
- NCIT_C576 inSubset NCIT_C63923 @default.
- NCIT_C576 type Class @default.
- NCIT_C576 isDefinedBy ncit.owl @default.
- NCIT_C576 label "Indomethacin" @default.
- NCIT_C576 subClassOf B35c51d03b0bb98bcb7411e5a4cca0642 @default.
- NCIT_C576 subClassOf Baac397955e5bc5ab5bc5affd7bf87a76 @default.
- NCIT_C576 subClassOf NCIT_C1323 @default.
- NCIT_C576 subClassOf NCIT_C1908 @default.
- NCIT_C576 subClassOf NCIT_C1909 @default.
- NCIT_C576 subClassOf NCIT_C1913 @default.
- NCIT_C576 subClassOf NCIT_C1915 @default.
- NCIT_C576 subClassOf NCIT_C1933 @default.
- NCIT_C576 subClassOf NCIT_C2198 @default.
- NCIT_C576 subClassOf NCIT_C2356 @default.
- NCIT_C576 subClassOf NCIT_C241 @default.
- NCIT_C576 subClassOf NCIT_C257 @default.
- NCIT_C576 subClassOf NCIT_C471 @default.
- NCIT_C576 subClassOf NCIT_C54677 @default.
- NCIT_C576 subClassOf NCIT_C576 @default.
- NCIT_C576 subClassOf NCIT_C718 @default.
- NCIT_C576 subClassOf NCIT_C78272 @default.