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- NCIT_C591 IAO_0000115 "A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin-6 (IL-6) with antiapoptotic, proinflammatory, antiinflammatory, proproliferative and proangiogenic activities. IL-6 binds to its receptor (IL-6R), activating a receptor-CD130 receptor complex; the CD130 portion of the complex is a signal transduction protein that activates JAK kinases and Ras-mediated signaling pathways, which in turn activate downstream signaling pathways, resulting in the activation of various transcription factors (STAT, ELK-1, NF-IL-6, etc.) and gene transcription. The physiological effects of IL-6 are complex and varied and include hematopoietic, pyrogenic and thermogenic, proinflammatory, antiinflammatory, proproliferative (anti-apoptotic), and angiogenic effects." @default.
- NCIT_C591 NCIT_A32 NCIT_C1909 @default.
- NCIT_C591 NCIT_A7 NCIT_C38921 @default.
- NCIT_C591 NCIT_NHC0 "C591" @default.
- NCIT_C591 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C591 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C591 NCIT_P107 "Recombinant Interleukin-6" @default.
- NCIT_C591 NCIT_P108 "Recombinant Interleukin-6" @default.
- NCIT_C591 NCIT_P207 "C1527132" @default.
- NCIT_C591 NCIT_P319 "4O4QWG0B3C" @default.
- NCIT_C591 NCIT_P322 "CTRP" @default.
- NCIT_C591 NCIT_P322 "FDA" @default.
- NCIT_C591 NCIT_P322 "GDC" @default.
- NCIT_C591 NCIT_P325 "One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukin-6 is made mainly by some T lymphocytes. It causes B lymphocytes to make more antibodies and also causes fever by affecting areas of the brain that control body temperature. Interleukin-6 made in the laboratory is used as a biological response modifier to boost the immune system in cancer therapy. Interleukin-6 is a type of cytokine." @default.
- NCIT_C591 NCIT_P329 "41474" @default.
- NCIT_C591 NCIT_P330 "41474" @default.
- NCIT_C591 NCIT_P366 "Therapeutic_Interleukin-6" @default.
- NCIT_C591 NCIT_P375 "Recombinant Interleukin-6" @default.
- NCIT_C591 NCIT_P399 "41474" @default.
- NCIT_C591 NCIT_R124 NCIT_C17828 @default.
- NCIT_C591 NCIT_R124 NCIT_C18992 @default.
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- NCIT_C591 NCIT_R124 NCIT_C21124 @default.
- NCIT_C591 NCIT_R124 NCIT_C40702 @default.
- NCIT_C591 NCIT_R124 NCIT_C45547 @default.
- NCIT_C591 NCIT_R125 NCIT_C16674 @default.
- NCIT_C591 NCIT_R125 NCIT_C17828 @default.
- NCIT_C591 NCIT_R125 NCIT_C17932 @default.
- NCIT_C591 NCIT_R125 NCIT_C17937 @default.
- NCIT_C591 NCIT_R125 NCIT_C18081 @default.
- NCIT_C591 NCIT_R125 NCIT_C18095 @default.
- NCIT_C591 NCIT_R125 NCIT_C18839 @default.
- NCIT_C591 NCIT_R125 NCIT_C18992 @default.
- NCIT_C591 NCIT_R125 NCIT_C19143 @default.
- NCIT_C591 NCIT_R125 NCIT_C19932 @default.
- NCIT_C591 NCIT_R125 NCIT_C20480 @default.
- NCIT_C591 NCIT_R125 NCIT_C20751 @default.
- NCIT_C591 NCIT_R125 NCIT_C21124 @default.
- NCIT_C591 NCIT_R125 NCIT_C21128 @default.
- NCIT_C591 NCIT_R125 NCIT_C21147 @default.
- NCIT_C591 NCIT_R125 NCIT_C26044 @default.
- NCIT_C591 NCIT_R125 NCIT_C40584 @default.
- NCIT_C591 NCIT_R125 NCIT_C40588 @default.
- NCIT_C591 NCIT_R125 NCIT_C40702 @default.
- NCIT_C591 NCIT_R125 NCIT_C40727 @default.
- NCIT_C591 NCIT_R125 NCIT_C40739 @default.
- NCIT_C591 NCIT_R125 NCIT_C40912 @default.
- NCIT_C591 NCIT_R125 NCIT_C41515 @default.
- NCIT_C591 NCIT_R125 NCIT_C51037 @default.
- NCIT_C591 NCIT_R146 NCIT_C156001 @default.
- NCIT_C591 NCIT_R146 NCIT_C17021 @default.
- NCIT_C591 NCIT_R146 NCIT_C17667 @default.
- NCIT_C591 NCIT_R146 NCIT_C17728 @default.
- NCIT_C591 NCIT_R146 NCIT_C18106 @default.
- NCIT_C591 NCIT_R146 NCIT_C20027 @default.
- NCIT_C591 NCIT_R146 NCIT_C26548 @default.
- NCIT_C591 NCIT_R146 NCIT_C38921 @default.
- NCIT_C591 normalizedInformationContent "83.027314241919257" @default.
- NCIT_C591 referenceCount "13" @default.
- NCIT_C591 hasExactSynonym "B Cell Differentiation Factor 2" @default.
- NCIT_C591 hasExactSynonym "B-Cell Stimulatory Factor-2" @default.
- NCIT_C591 hasExactSynonym "HPGF" @default.
- NCIT_C591 hasExactSynonym "HSF" @default.
- NCIT_C591 hasExactSynonym "HUMAN INTERLEUKIN-6" @default.
- NCIT_C591 hasExactSynonym "Hepatocyte Stimulating Factor" @default.
- NCIT_C591 hasExactSynonym "Hybridoma Growth Factor" @default.
- NCIT_C591 hasExactSynonym "IFN Beta 2" @default.
- NCIT_C591 hasExactSynonym "IL-6" @default.
- NCIT_C591 hasExactSynonym "Interleukin-6" @default.
- NCIT_C591 hasExactSynonym "Myeloid Differentiation Inducing Protein" @default.
- NCIT_C591 hasExactSynonym "Plasmacytoma Growth Factor" @default.
- NCIT_C591 hasExactSynonym "Recombinant Interleukin-6" @default.
- NCIT_C591 hasExactSynonym "Sigosix" @default.
- NCIT_C591 inSubset NCIT_C116977 @default.
- NCIT_C591 inSubset NCIT_C116978 @default.
- NCIT_C591 inSubset NCIT_C128784 @default.
- NCIT_C591 inSubset NCIT_C157711 @default.
- NCIT_C591 inSubset NCIT_C157712 @default.
- NCIT_C591 inSubset NCIT_C176424 @default.
- NCIT_C591 inSubset NCIT_C177537 @default.
- NCIT_C591 inSubset NCIT_C63923 @default.
- NCIT_C591 type Class @default.
- NCIT_C591 isDefinedBy ncit.owl @default.
- NCIT_C591 label "Recombinant Interleukin-6" @default.
- NCIT_C591 subClassOf NCIT_C1283 @default.
- NCIT_C591 subClassOf NCIT_C1908 @default.
- NCIT_C591 subClassOf NCIT_C1909 @default.
- NCIT_C591 subClassOf NCIT_C2259 @default.
- NCIT_C591 subClassOf NCIT_C2260 @default.
- NCIT_C591 subClassOf NCIT_C307 @default.
- NCIT_C591 subClassOf NCIT_C308 @default.
- NCIT_C591 subClassOf NCIT_C530 @default.
- NCIT_C591 subClassOf NCIT_C591 @default.
- NCIT_C591 subClassOf NCIT_C593 @default.
- NCIT_C591 equivalentClass B4308a76b903926107ebdbf9c510bcd27 @default.
- NCIT_C591 equivalentClass B6bccb86308ae6f673f4763dc1081e2a2 @default.