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- NCIT_C600 IAO_0000115 "A synthetic derivative of nicotinic acid with anti-mycobacterial properties. Although its mechanism of action is still unclear, isoniazid appears to block the synthesis of mycolic acids, major components of the mycobacterial cell wall. This agent is only active against actively growing mycobacteria because, as a pro-drug, it requires activation in susceptible mycobacterial species. Isoniazid also interferes with mycobacterial metabolism of vitamin B6. Resistance occurs due to decreased bacterial wall penetration. (NCI04)" @default.
- NCIT_C600 NCIT_NHC0 "C600" @default.
- NCIT_C600 NCIT_P106 "Organic Chemical" @default.
- NCIT_C600 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C600 NCIT_P108 "Isoniazid" @default.
- NCIT_C600 NCIT_P175 "9659" @default.
- NCIT_C600 NCIT_P207 "C0022209" @default.
- NCIT_C600 NCIT_P210 "54-85-3" @default.
- NCIT_C600 NCIT_P319 "V83O1VOZ8L" @default.
- NCIT_C600 NCIT_P322 "FDA" @default.
- NCIT_C600 NCIT_P329 "39484" @default.
- NCIT_C600 NCIT_P330 "39484" @default.
- NCIT_C600 NCIT_P350 "C6H7N3O" @default.
- NCIT_C600 NCIT_P366 "Isoniazid" @default.
- NCIT_C600 NCIT_P368 "CHEBI:6030" @default.
- NCIT_C600 NCIT_P399 "39484" @default.
- NCIT_C600 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C600 referenceCount "2" @default.
- NCIT_C600 hasExactSynonym "ISONIAZID" @default.
- NCIT_C600 hasExactSynonym "Isoniazid" @default.
- NCIT_C600 hasExactSynonym "Isonicotinic Acid Hydrazide" @default.
- NCIT_C600 hasExactSynonym "Isonicotinyl Hydrazine" @default.
- NCIT_C600 inSubset NCIT_C176424 @default.
- NCIT_C600 inSubset NCIT_C63923 @default.
- NCIT_C600 type Class @default.
- NCIT_C600 isDefinedBy ncit.owl @default.
- NCIT_C600 label "Isoniazid" @default.
- NCIT_C600 subClassOf NCIT_C1908 @default.
- NCIT_C600 subClassOf NCIT_C1909 @default.
- NCIT_C600 subClassOf NCIT_C254 @default.
- NCIT_C600 subClassOf NCIT_C280 @default.
- NCIT_C600 subClassOf NCIT_C52588 @default.
- NCIT_C600 subClassOf NCIT_C600 @default.