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- NCIT_C60766 IAO_0000115 "An indium In 111-labeled trastuzumab with potential use as an imaging agent. Indium In 111 CHX-A DTPA trastuzumab is chemically conjugated via a bifunctional metal chelator molecule, 2-(p-isothiocyanatobenzyl)-cyclohexyl-diethylenetriaminepentaacetic acid (CHX-A DTPA), a backbone-substituted derivative of DTPA. This agent may allow radioimmunolocalization of HER2-positive cells. Trastuzumab, a recombinant humanized monoclonal antibody that selectively binds with high affinity to the extracellular domain of human epidermal growth factor receptor 2 (HER2), may elicit an antibody-dependent cellular cytotoxicity (ADCC) against tumor cells that overexpress HER2." @default.
- NCIT_C60766 NCIT_A7 NCIT_C17319 @default.
- NCIT_C60766 NCIT_NHC0 "C60766" @default.
- NCIT_C60766 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C60766 NCIT_P106 "Indicator, Reagent, or Diagnostic Aid" @default.
- NCIT_C60766 NCIT_P107 "Indium In 111 CHX-A DTPA Trastuzumab" @default.
- NCIT_C60766 NCIT_P108 "Indium In 111 CHX-A DTPA Trastuzumab" @default.
- NCIT_C60766 NCIT_P175 "740377" @default.
- NCIT_C60766 NCIT_P208 "CL360663" @default.
- NCIT_C60766 NCIT_P322 "CTRP" @default.
- NCIT_C60766 NCIT_P325 "A substance being studied in the imaging of breast cancer and some other types of cancer. It is made by attaching a radioactive substance called indium 111 to the monoclonal antibody trastuzumab (Herceptin). Trastuzumab binds to the human growth factor receptor 2 (HER2/neu) on some breast cancer cells and on several other types of cancer cells. Indium In 111 CHX-A DTPA trastuzumab is a type of radioimmunoconjugate." @default.
- NCIT_C60766 NCIT_P329 "543723" @default.
- NCIT_C60766 NCIT_P330 "543723" @default.
- NCIT_C60766 NCIT_P366 "Indium-CHX-A_DTPA-Trastuzumab" @default.
- NCIT_C60766 NCIT_P399 "543723" @default.
- NCIT_C60766 normalizedInformationContent "100" @default.
- NCIT_C60766 referenceCount "1" @default.
- NCIT_C60766 hasExactSynonym "111In-CHX-A"-DTPA-Trastuzumab" @default.
- NCIT_C60766 hasExactSynonym "Indium In 111 CHX-A DTPA Trastuzumab" @default.
- NCIT_C60766 hasExactSynonym "indium In 111 CHX-A DTPA trastuzumab" @default.
- NCIT_C60766 inSubset NCIT_C116977 @default.
- NCIT_C60766 inSubset NCIT_C116978 @default.
- NCIT_C60766 inSubset NCIT_C176424 @default.
- NCIT_C60766 type Class @default.
- NCIT_C60766 isDefinedBy ncit.owl @default.
- NCIT_C60766 label "Indium In 111 CHX-A DTPA Trastuzumab" @default.
- NCIT_C60766 subClassOf NCIT_C1446 @default.
- NCIT_C60766 subClassOf NCIT_C1511 @default.
- NCIT_C60766 subClassOf NCIT_C1512 @default.
- NCIT_C60766 subClassOf NCIT_C1908 @default.
- NCIT_C60766 subClassOf NCIT_C1909 @default.
- NCIT_C60766 subClassOf NCIT_C2124 @default.
- NCIT_C60766 subClassOf NCIT_C307 @default.
- NCIT_C60766 subClassOf NCIT_C308 @default.
- NCIT_C60766 subClassOf NCIT_C60766 @default.