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- NCIT_C60768 IAO_0000115 "A poly(ADP-ribose) polymerase (PARP) -1 and -2 inhibitor with chemosensitizing and antitumor activities. With no antiproliferative effects as a single agent at therapeutic concentrations, ABT-888 inhibits PARPs, thereby inhibiting DNA repair and potentiating the cytotoxicity of DNA-damaging agents. PARP nuclear enzymes are activated by DNA single or double strand breaks, resulting in the poly(ADP-ribosyl)ation of other nuclear DNA binding proteins involved in DNA repair; poly(ADP-ribosyl)ation contributes to efficient DNA repair and to survival of proliferating cells exposed to mild genotoxic stresses as induced by as oxidants, alkylating agents or ionizing radiation." @default.
- NCIT_C60768 NCIT_A32 NCIT_C1909 @default.
- NCIT_C60768 NCIT_A7 NCIT_C48215 @default.
- NCIT_C60768 NCIT_NHC0 "C60768" @default.
- NCIT_C60768 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C60768 NCIT_P107 "Veliparib" @default.
- NCIT_C60768 NCIT_P108 "Veliparib" @default.
- NCIT_C60768 NCIT_P175 "737664" @default.
- NCIT_C60768 NCIT_P207 "C1958300" @default.
- NCIT_C60768 NCIT_P210 "912444-00-9" @default.
- NCIT_C60768 NCIT_P319 "01O4K0631N" @default.
- NCIT_C60768 NCIT_P322 "CTRP" @default.
- NCIT_C60768 NCIT_P322 "FDA" @default.
- NCIT_C60768 NCIT_P322 "GDC" @default.
- NCIT_C60768 NCIT_P325 "A substance being studied in the treatment of breast cancers caused by mutations (changes) in the BRCA1 and BRCA2 genes. It is also being studied in the treatment of other types of cancer. It blocks an enzyme involved in many functions of the cell, including the repair of DNA damage. DNA damage may be caused by normal cell actions, UV light, some anticancer drugs, and radiation used to treat cancer. ABT-888 may cause cancer cells to die. It is a type of poly(ADP-ribose) polymerase inhibitor." @default.
- NCIT_C60768 NCIT_P329 "496464" @default.
- NCIT_C60768 NCIT_P330 "496464" @default.
- NCIT_C60768 NCIT_P350 "C13H16N4O" @default.
- NCIT_C60768 NCIT_P366 "ABT-888" @default.
- NCIT_C60768 NCIT_P368 "CHEBI:62880" @default.
- NCIT_C60768 NCIT_P375 "Veliparib" @default.
- NCIT_C60768 NCIT_P399 "496464" @default.
- NCIT_C60768 NCIT_R146 NCIT_C104101 @default.
- NCIT_C60768 NCIT_R146 NCIT_C16554 @default.
- NCIT_C60768 NCIT_R146 NCIT_C17021 @default.
- NCIT_C60768 NCIT_R146 NCIT_C17210 @default.
- NCIT_C60768 NCIT_R146 NCIT_C17434 @default.
- NCIT_C60768 NCIT_R146 NCIT_C20027 @default.
- NCIT_C60768 NCIT_R146 NCIT_C21170 @default.
- NCIT_C60768 NCIT_R146 NCIT_C26548 @default.
- NCIT_C60768 NCIT_R146 NCIT_C48215 @default.
- NCIT_C60768 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C60768 referenceCount "2" @default.
- NCIT_C60768 hasExactSynonym "2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide" @default.
- NCIT_C60768 hasExactSynonym "ABT-888" @default.
- NCIT_C60768 hasExactSynonym "PARP-1 inhibitor ABT-888" @default.
- NCIT_C60768 hasExactSynonym "VELIPARIB" @default.
- NCIT_C60768 hasExactSynonym "Veliparib" @default.
- NCIT_C60768 hasExactSynonym "veliparib" @default.
- NCIT_C60768 inSubset NCIT_C116977 @default.
- NCIT_C60768 inSubset NCIT_C116978 @default.
- NCIT_C60768 inSubset NCIT_C128784 @default.
- NCIT_C60768 inSubset NCIT_C157711 @default.
- NCIT_C60768 inSubset NCIT_C157712 @default.
- NCIT_C60768 inSubset NCIT_C176424 @default.
- NCIT_C60768 inSubset NCIT_C177537 @default.
- NCIT_C60768 inSubset NCIT_C63923 @default.
- NCIT_C60768 type Class @default.
- NCIT_C60768 isDefinedBy ncit.owl @default.
- NCIT_C60768 label "Veliparib" @default.
- NCIT_C60768 subClassOf NCIT_C163758 @default.
- NCIT_C60768 subClassOf NCIT_C1908 @default.
- NCIT_C60768 subClassOf NCIT_C1909 @default.
- NCIT_C60768 subClassOf NCIT_C274 @default.
- NCIT_C60768 subClassOf NCIT_C471 @default.
- NCIT_C60768 subClassOf NCIT_C60768 @default.
- NCIT_C60768 subClassOf NCIT_C62554 @default.