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- NCIT_C60769 IAO_0000115 "A sesquiterpene lactone peroxide and dimerized plant product derived from Artemisia annua L with anti-malarial, anti-proliferative and anti-angiogenic effects. Artemisinin contains an endoperoxide moiety which forms free radicals when it reacts with iron. The resultant carbon-based radical can lead to cellular damage and cell death by reacting with cellular macromolecules such as proteins and membrane lipids. Malaria parasites contain large amounts of heme-iron, a product from the digestion of hemoglobin. However, recently it has been suggested that activation of artemisinin inside the parasite is by ferrous iron. Furthermore, due to their rapid rate of division, cancer cells require and uptake a large amount of iron to proliferate, therefore they are more susceptible to the cytotoxic effect of artemisinin than non-cancerous cells. The dimer configuration has been shown to increase compound stability and reduce general toxicity." @default.
- NCIT_C60769 NCIT_A32 NCIT_C1909 @default.
- NCIT_C60769 NCIT_A7 NCIT_C598 @default.
- NCIT_C60769 NCIT_A7 NCIT_C98268 @default.
- NCIT_C60769 NCIT_NHC0 "C60769" @default.
- NCIT_C60769 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C60769 NCIT_P108 "Artemisinin Dimer" @default.
- NCIT_C60769 NCIT_P175 "724910" @default.
- NCIT_C60769 NCIT_P207 "C1879739" @default.
- NCIT_C60769 NCIT_P322 "GDC" @default.
- NCIT_C60769 NCIT_P366 "Artemisinin_Dimer" @default.
- NCIT_C60769 NCIT_P375 "Artemisinin Dimer" @default.
- NCIT_C60769 normalizedInformationContent "100" @default.
- NCIT_C60769 referenceCount "1" @default.
- NCIT_C60769 hasExactSynonym "Artemisinin Dimer" @default.
- NCIT_C60769 inSubset NCIT_C128784 @default.
- NCIT_C60769 inSubset NCIT_C157711 @default.
- NCIT_C60769 inSubset NCIT_C157712 @default.
- NCIT_C60769 inSubset NCIT_C177537 @default.
- NCIT_C60769 type Class @default.
- NCIT_C60769 isDefinedBy ncit.owl @default.
- NCIT_C60769 label "Artemisinin Dimer" @default.
- NCIT_C60769 subClassOf NCIT_C1908 @default.
- NCIT_C60769 subClassOf NCIT_C1909 @default.
- NCIT_C60769 subClassOf NCIT_C1913 @default.
- NCIT_C60769 subClassOf NCIT_C254 @default.
- NCIT_C60769 subClassOf NCIT_C271 @default.
- NCIT_C60769 subClassOf NCIT_C276 @default.
- NCIT_C60769 subClassOf NCIT_C277 @default.
- NCIT_C60769 subClassOf NCIT_C552 @default.
- NCIT_C60769 subClassOf NCIT_C60769 @default.
- NCIT_C60769 subClassOf NCIT_C616 @default.
- NCIT_C60769 subClassOf NCIT_C718 @default.
- NCIT_C60769 subClassOf NCIT_C860 @default.