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- NCIT_C60770 IAO_0000115 "A small molecule and a pan-inhibitor of Bcl-2 family proteins, with pro-apoptotic activity. GX015-070 is a selective antagonist of the BH3-binding groove of the Bcl-2 family proteins, which are frequently overexpressed in cancers including chronic lymphocytic leukemia (CLL). This agent induces/restores apoptosis in cancer cells by inhibiting apoptosis suppressors in multiple members of the Bcl-2 family simultaneously." @default.
- NCIT_C60770 NCIT_A5 NCIT_C62771 @default.
- NCIT_C60770 NCIT_A7 NCIT_C20409 @default.
- NCIT_C60770 NCIT_NHC0 "C60770" @default.
- NCIT_C60770 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C60770 NCIT_P108 "Obatoclax" @default.
- NCIT_C60770 NCIT_P171 "19118042" @default.
- NCIT_C60770 NCIT_P175 "729280" @default.
- NCIT_C60770 NCIT_P207 "C2713011" @default.
- NCIT_C60770 NCIT_P210 "803712-67-6" @default.
- NCIT_C60770 NCIT_P319 "QN4128B52A" @default.
- NCIT_C60770 NCIT_P322 "FDA" @default.
- NCIT_C60770 NCIT_P325 "A substance being studied in the treatment of several types of cancer. Obatoclax blocks the actions of certain proteins that cells need to live and it may kill cancer cells. It is a type of apoptosis inducer, a BCL2 protein antagonist, and a BH3 mimetic." @default.
- NCIT_C60770 NCIT_P350 "C20H19N3O" @default.
- NCIT_C60770 NCIT_P366 "GX015-070" @default.
- NCIT_C60770 normalizedInformationContent "100" @default.
- NCIT_C60770 referenceCount "1" @default.
- NCIT_C60770 hasExactSynonym "1H-Indole, 2-(2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-" @default.
- NCIT_C60770 hasExactSynonym "GX015-070" @default.
- NCIT_C60770 hasExactSynonym "OBATOCLAX" @default.
- NCIT_C60770 hasExactSynonym "Obatoclax" @default.
- NCIT_C60770 hasExactSynonym "obatoclax" @default.
- NCIT_C60770 inSubset NCIT_C63923 @default.
- NCIT_C60770 type Class @default.
- NCIT_C60770 isDefinedBy ncit.owl @default.
- NCIT_C60770 label "Obatoclax" @default.
- NCIT_C60770 subClassOf NCIT_C129839 @default.
- NCIT_C60770 subClassOf NCIT_C159200 @default.
- NCIT_C60770 subClassOf NCIT_C163758 @default.
- NCIT_C60770 subClassOf NCIT_C1908 @default.
- NCIT_C60770 subClassOf NCIT_C1909 @default.
- NCIT_C60770 subClassOf NCIT_C192025 @default.
- NCIT_C60770 subClassOf NCIT_C274 @default.
- NCIT_C60770 subClassOf NCIT_C60770 @default.