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- NCIT_C60773 IAO_0000115 "An organic nitrate with vasodilator activity. Isosorbide relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle. Elevated cGMP levels in smooth muscle activate cGMP-dependent kinase activity that leads to release of sequestered Ca2+. In turn, free Ca+ triggers dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition isosorbide relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area." @default.
- NCIT_C60773 NCIT_A5 NCIT_C29134 @default.
- NCIT_C60773 NCIT_A5 NCIT_C47575 @default.
- NCIT_C60773 NCIT_A7 NCIT_C39169 @default.
- NCIT_C60773 NCIT_NHC0 "C60773" @default.
- NCIT_C60773 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C60773 NCIT_P108 "Isosorbide" @default.
- NCIT_C60773 NCIT_P175 "40725" @default.
- NCIT_C60773 NCIT_P207 "C0022251" @default.
- NCIT_C60773 NCIT_P210 "652-67-5" @default.
- NCIT_C60773 NCIT_P319 "WXR179L51S" @default.
- NCIT_C60773 NCIT_P322 "FDA" @default.
- NCIT_C60773 NCIT_P350 "C6H10O4" @default.
- NCIT_C60773 NCIT_P366 "Isosorbide" @default.
- NCIT_C60773 normalizedInformationContent "100" @default.
- NCIT_C60773 referenceCount "1" @default.
- NCIT_C60773 hasExactSynonym "ISOSORBIDE" @default.
- NCIT_C60773 hasExactSynonym "Ismotic" @default.
- NCIT_C60773 hasExactSynonym "Isosorbide" @default.
- NCIT_C60773 inSubset NCIT_C63923 @default.
- NCIT_C60773 type Class @default.
- NCIT_C60773 isDefinedBy ncit.owl @default.
- NCIT_C60773 label "Isosorbide" @default.
- NCIT_C60773 subClassOf NCIT_C1908 @default.
- NCIT_C60773 subClassOf NCIT_C1909 @default.
- NCIT_C60773 subClassOf NCIT_C29707 @default.
- NCIT_C60773 subClassOf NCIT_C60773 @default.
- NCIT_C60773 subClassOf NCIT_C78274 @default.