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- NCIT_C60774 IAO_0000115 "An isolate of the oncolytic, human wild-type serotype 3 Dearing (T3D) strain of the double-stranded RNA virus reovirus (Respiratory Enteric Orphan virus), with potential oncolytic activity. Upon administration, pelareorep is able to replicate specifically in cancer cells bearing an activated Ras pathway. This induces apoptosis in Ras-activated tumor cells and subsequently frees progeny viral particles to infect, replicate in and induce cell death of surrounding cancer cells. In addition, viral replication causes the activation of innate and adaptive immune responses, causing a natural killer (NK)-cell-mediated and a cytotoxic T-cell (CTL)-mediated killing of tumor cells, respectively. Ras-activated tumor cells are deficient in their ability to trigger the antiviral response mediated by the host cellular protein, double-stranded RNA-dependent protein kinase (PKR)." @default.
- NCIT_C60774 NCIT_A32 NCIT_C1909 @default.
- NCIT_C60774 NCIT_A7 NCIT_C38344 @default.
- NCIT_C60774 NCIT_NHC0 "C60774" @default.
- NCIT_C60774 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C60774 NCIT_P107 "Pelareorep" @default.
- NCIT_C60774 NCIT_P108 "Pelareorep" @default.
- NCIT_C60774 NCIT_P175 "729968" @default.
- NCIT_C60774 NCIT_P207 "C1882931" @default.
- NCIT_C60774 NCIT_P210 "1383626-61-6" @default.
- NCIT_C60774 NCIT_P319 "S9J80L3D1U" @default.
- NCIT_C60774 NCIT_P322 "CTRP" @default.
- NCIT_C60774 NCIT_P322 "FDA" @default.
- NCIT_C60774 NCIT_P322 "GDC" @default.
- NCIT_C60774 NCIT_P329 "563224" @default.
- NCIT_C60774 NCIT_P330 "563224" @default.
- NCIT_C60774 NCIT_P366 "Reolysin" @default.
- NCIT_C60774 NCIT_P375 "Pelareorep" @default.
- NCIT_C60774 NCIT_P399 "563224" @default.
- NCIT_C60774 normalizedInformationContent "100" @default.
- NCIT_C60774 referenceCount "1" @default.
- NCIT_C60774 hasExactSynonym "PELAREOREP" @default.
- NCIT_C60774 hasExactSynonym "PO BB0209" @default.
- NCIT_C60774 hasExactSynonym "PO-BB0209" @default.
- NCIT_C60774 hasExactSynonym "Pelareorep" @default.
- NCIT_C60774 hasExactSynonym "Reolysin" @default.
- NCIT_C60774 hasExactSynonym "Reovirus Serotype 3" @default.
- NCIT_C60774 hasExactSynonym "Wild-type Reovirus" @default.
- NCIT_C60774 inSubset NCIT_C116977 @default.
- NCIT_C60774 inSubset NCIT_C116978 @default.
- NCIT_C60774 inSubset NCIT_C128784 @default.
- NCIT_C60774 inSubset NCIT_C157711 @default.
- NCIT_C60774 inSubset NCIT_C157712 @default.
- NCIT_C60774 inSubset NCIT_C176424 @default.
- NCIT_C60774 inSubset NCIT_C177537 @default.
- NCIT_C60774 inSubset NCIT_C63923 @default.
- NCIT_C60774 type Class @default.
- NCIT_C60774 isDefinedBy ncit.owl @default.
- NCIT_C60774 label "Pelareorep" @default.
- NCIT_C60774 subClassOf NCIT_C129821 @default.
- NCIT_C60774 subClassOf NCIT_C1908 @default.
- NCIT_C60774 subClassOf NCIT_C1909 @default.
- NCIT_C60774 subClassOf NCIT_C274 @default.
- NCIT_C60774 subClassOf NCIT_C307 @default.
- NCIT_C60774 subClassOf NCIT_C60774 @default.
- NCIT_C60774 subClassOf NCIT_C717 @default.