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- NCIT_C60775 IAO_0000115 "A synthetic cytokine and interleukin-3 (IL-3) receptor agonist with enhanced hematopoietic potency. Daniplestim exhibits 10- to 20-fold greater biological activity than recombinant human IL-3 in human hematopoietic cell proliferation and marrow colony-forming-unit assays. In contrast, this agent shows no significant increase in pro-inflammatory activity relative to native IL-3. The enhanced hematopoietic activity of daniplestim correlates with a 60-fold increase in IL-3 alpha-subunit binding affinity and 20-fold greater affinity for binding to alpha/beta receptor complexes on intact cells relative to recombinant IL-3." @default.
- NCIT_C60775 NCIT_A7 NCIT_C39273 @default.
- NCIT_C60775 NCIT_NHC0 "C60775" @default.
- NCIT_C60775 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C60775 NCIT_P108 "Daniplestim" @default.
- NCIT_C60775 NCIT_P207 "C0297038" @default.
- NCIT_C60775 NCIT_P210 "161753-30-6" @default.
- NCIT_C60775 NCIT_P319 "491EKS8W4C" @default.
- NCIT_C60775 NCIT_P322 "FDA" @default.
- NCIT_C60775 NCIT_P366 "Daniplestim" @default.
- NCIT_C60775 NCIT_R125 NCIT_C17828 @default.
- NCIT_C60775 NCIT_R125 NCIT_C18081 @default.
- NCIT_C60775 NCIT_R125 NCIT_C20480 @default.
- NCIT_C60775 NCIT_R125 NCIT_C20751 @default.
- NCIT_C60775 normalizedInformationContent "100" @default.
- NCIT_C60775 referenceCount "1" @default.
- NCIT_C60775 hasExactSynonym "DANIPLESTIM" @default.
- NCIT_C60775 hasExactSynonym "Daniplestim" @default.
- NCIT_C60775 hasExactSynonym "SC-55494" @default.
- NCIT_C60775 hasExactSynonym "Synthokine" @default.
- NCIT_C60775 inSubset NCIT_C63923 @default.
- NCIT_C60775 type Class @default.
- NCIT_C60775 isDefinedBy ncit.owl @default.
- NCIT_C60775 label "Daniplestim" @default.
- NCIT_C60775 subClassOf NCIT_C1283 @default.
- NCIT_C60775 subClassOf NCIT_C1908 @default.
- NCIT_C60775 subClassOf NCIT_C1909 @default.
- NCIT_C60775 subClassOf NCIT_C307 @default.
- NCIT_C60775 subClassOf NCIT_C308 @default.
- NCIT_C60775 subClassOf NCIT_C593 @default.
- NCIT_C60775 subClassOf NCIT_C60775 @default.