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- NCIT_C60809 IAO_0000115 "A synthetic quinolone derivative and dual kinase inhibitor that targets both Abl and Src kinases with potential antineoplastic activity. Unlike imatinib, bosutinib inhibits the autophosphorylation of both Abl and Src kinases, resulting in inhibition of cell growth and apoptosis. Because of the dual mechanism of action, this agent may have activity in resistant CML disease, other myeloid malignancies and solid tumors. Abl kinase is upregulated in the presence of the abnormal Bcr-abl fusion protein which is commonly associated with chronic myeloid leukemia (CML). Overexpression of specific Src kinases is also associated with the imatinib-resistant CML phenotype." @default.
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- NCIT_C60809 NCIT_P106 "Organic Chemical" @default.
- NCIT_C60809 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C60809 NCIT_P107 "Bosutinib" @default.
- NCIT_C60809 NCIT_P108 "Bosutinib" @default.
- NCIT_C60809 NCIT_P207 "C1831731" @default.
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- NCIT_C60809 NCIT_P329 "467222" @default.
- NCIT_C60809 NCIT_P330 "467222" @default.
- NCIT_C60809 NCIT_P350 "C26H29Cl2N5O3" @default.
- NCIT_C60809 NCIT_P366 "Bosutinib" @default.
- NCIT_C60809 NCIT_P368 "CHEBI:39112" @default.
- NCIT_C60809 NCIT_P375 "Bosutinib" @default.
- NCIT_C60809 NCIT_P399 "467222" @default.
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- NCIT_C60809 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C60809 referenceCount "2" @default.
- NCIT_C60809 hasExactSynonym "4-Anilino-3-quinolinecarbonitrile" @default.
- NCIT_C60809 hasExactSynonym "4-Anilinobenzo(g)quinoline-3-carbonitrile" @default.
- NCIT_C60809 hasExactSynonym "4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile" @default.
- NCIT_C60809 hasExactSynonym "BOSUTINIB" @default.
- NCIT_C60809 hasExactSynonym "Bosutinib" @default.
- NCIT_C60809 hasExactSynonym "SKI 606" @default.
- NCIT_C60809 hasExactSynonym "SKI-606" @default.
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- NCIT_C60809 type Class @default.
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- NCIT_C60809 label "Bosutinib" @default.
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