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- NCIT_C60816 IAO_0000115 "A second generation polyamine analogue, synthesized through the restriction of molecular conformations of parent polyamine compounds, with potential antineoplastic activity. Polyamine analogue PG11047 may displace endogenous polyamines from DNA binding sites, thereby interfering with cell cycle processes dependent upon polyamine binding and function, and resulting in cell-cycle arrest, induction of apoptosis, depletion of polyamines, and interference with gene and ligand-receptor activities involved with cell growth. This agent may exhibit decreased toxicity and enhanced cytotoxicity profiles compared to first-generation polyamine compounds. In tumor cells, there is an increase dependence on polyamines as well as a dysregulated polyamine metabolic pathway resulting in abnormal or sustained tumor growth." @default.
- NCIT_C60816 NCIT_A32 NCIT_C1909 @default.
- NCIT_C60816 NCIT_NHC0 "C60816" @default.
- NCIT_C60816 NCIT_P106 "Organic Chemical" @default.
- NCIT_C60816 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C60816 NCIT_P108 "Polyamine Analogue PG11047" @default.
- NCIT_C60816 NCIT_P207 "C1963112" @default.
- NCIT_C60816 NCIT_P210 "206991-64-2" @default.
- NCIT_C60816 NCIT_P319 "HU43305R7O" @default.
- NCIT_C60816 NCIT_P322 "FDA" @default.
- NCIT_C60816 NCIT_P322 "GDC" @default.
- NCIT_C60816 NCIT_P325 "A substance that is being studied in the treatment of lymphoma. It belongs to the family of drugs called polyamine analogs." @default.
- NCIT_C60816 NCIT_P329 "467739" @default.
- NCIT_C60816 NCIT_P330 "467739" @default.
- NCIT_C60816 NCIT_P366 "SL11047" @default.
- NCIT_C60816 NCIT_P375 "Polyamine Analogue PG11047" @default.
- NCIT_C60816 NCIT_P399 "467739" @default.
- NCIT_C60816 NCIT_R124 NCIT_C17710 @default.
- NCIT_C60816 NCIT_R124 NCIT_C17828 @default.
- NCIT_C60816 NCIT_R124 NCIT_C18219 @default.
- NCIT_C60816 NCIT_R124 NCIT_C18597 @default.
- NCIT_C60816 NCIT_R124 NCIT_C19986 @default.
- NCIT_C60816 NCIT_R124 NCIT_C40523 @default.
- NCIT_C60816 NCIT_R125 NCIT_C16399 @default.
- NCIT_C60816 NCIT_R125 NCIT_C17828 @default.
- NCIT_C60816 NCIT_R125 NCIT_C20150 @default.
- NCIT_C60816 NCIT_R125 NCIT_C20480 @default.
- NCIT_C60816 NCIT_R125 NCIT_C40715 @default.
- NCIT_C60816 NCIT_R125 NCIT_C40740 @default.
- NCIT_C60816 NCIT_R125 NCIT_C41515 @default.
- NCIT_C60816 NCIT_R125 NCIT_C51037 @default.
- NCIT_C60816 normalizedInformationContent "100" @default.
- NCIT_C60816 referenceCount "1" @default.
- NCIT_C60816 hasExactSynonym "BESpm" @default.
- NCIT_C60816 hasExactSynonym "CGC-11047" @default.
- NCIT_C60816 hasExactSynonym "N(1),-N(12)-bis(ethyl)-cis-6,7-dehydrospermine tetrahydrochloride" @default.
- NCIT_C60816 hasExactSynonym "N(1),-N(12)-bis(ethyl)-cis-6,7-dehydrospermine" @default.
- NCIT_C60816 hasExactSynonym "N(1),N(12)-bisethylspermine" @default.
- NCIT_C60816 hasExactSynonym "PG11047" @default.
- NCIT_C60816 hasExactSynonym "Polyamine Analogue PG11047" @default.
- NCIT_C60816 hasExactSynonym "SL-11047" @default.
- NCIT_C60816 hasExactSynonym "SL11047" @default.
- NCIT_C60816 inSubset NCIT_C128784 @default.
- NCIT_C60816 inSubset NCIT_C157711 @default.
- NCIT_C60816 inSubset NCIT_C157712 @default.
- NCIT_C60816 inSubset NCIT_C176424 @default.
- NCIT_C60816 inSubset NCIT_C177537 @default.
- NCIT_C60816 inSubset NCIT_C63923 @default.
- NCIT_C60816 type Class @default.
- NCIT_C60816 isDefinedBy ncit.owl @default.
- NCIT_C60816 label "Polyamine Analogue PG11047" @default.
- NCIT_C60816 subClassOf B27baf1244c3dcb959686ebcd0311603c @default.
- NCIT_C60816 subClassOf B2ad6707c017f93ce30503913ae8a790b @default.
- NCIT_C60816 subClassOf B442e17d9b755feea0841d1d64ae530f6 @default.
- NCIT_C60816 subClassOf B51f9ff6e1db1730e3b79cc906d64baca @default.
- NCIT_C60816 subClassOf Bd1568af16dd360b33604ed7ef5bd93d3 @default.
- NCIT_C60816 subClassOf Bfb5ff780d7e2eea07ddaae644ddfd15d @default.
- NCIT_C60816 subClassOf NCIT_C186664 @default.
- NCIT_C60816 subClassOf NCIT_C1908 @default.
- NCIT_C60816 subClassOf NCIT_C1909 @default.
- NCIT_C60816 subClassOf NCIT_C274 @default.
- NCIT_C60816 subClassOf NCIT_C2842 @default.
- NCIT_C60816 subClassOf NCIT_C49109 @default.
- NCIT_C60816 subClassOf NCIT_C60816 @default.