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- NCIT_C61070 IAO_0000115 "A pan alpha-v human monoclonal antibody that recognizes alpha-v beta-1, alpha-v beta-3, alpha-v beta-5, and alpha-v beta-6 integrins with antiangiogenic and antitumor activities. Intetumumab competitively binds to and blocks both alpha-v beta-3 and alpha-v beta-5 integrins, resulting in inhibition of integrin-mediated tumor angiogenesis and tumor growth. Integrins facilitate the adhesion of stimulated endothelial cells to the extracellular matrix (ECM); trigger the secretion of ECM-rearranging proteases; and propagate signaling events that promote the survival and differentiation of cells in newly formed vasculature." @default.
- NCIT_C61070 NCIT_A32 NCIT_C1909 @default.
- NCIT_C61070 NCIT_A7 NCIT_C124258 @default.
- NCIT_C61070 NCIT_A7 NCIT_C177732 @default.
- NCIT_C61070 NCIT_A7 NCIT_C38953 @default.
- NCIT_C61070 NCIT_A7 NCIT_C53624 @default.
- NCIT_C61070 NCIT_NHC0 "C61070" @default.
- NCIT_C61070 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C61070 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61070 NCIT_P107 "Intetumumab" @default.
- NCIT_C61070 NCIT_P108 "Intetumumab" @default.
- NCIT_C61070 NCIT_P207 "C1881068" @default.
- NCIT_C61070 NCIT_P210 "725735-28-4" @default.
- NCIT_C61070 NCIT_P319 "GQE1BJE2NI" @default.
- NCIT_C61070 NCIT_P322 "CTRP" @default.
- NCIT_C61070 NCIT_P322 "FDA" @default.
- NCIT_C61070 NCIT_P322 "GDC" @default.
- NCIT_C61070 NCIT_P329 "473196" @default.
- NCIT_C61070 NCIT_P330 "473196" @default.
- NCIT_C61070 NCIT_P366 "Human_Anti-Alpha-5_Integrin_Monoclonal_Antibody" @default.
- NCIT_C61070 NCIT_P375 "Intetumumab" @default.
- NCIT_C61070 NCIT_P399 "473196" @default.
- NCIT_C61070 NCIT_R124 NCIT_C17710 @default.
- NCIT_C61070 NCIT_R124 NCIT_C17828 @default.
- NCIT_C61070 NCIT_R124 NCIT_C18219 @default.
- NCIT_C61070 NCIT_R124 NCIT_C19986 @default.
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- NCIT_C61070 NCIT_R146 NCIT_C16393 @default.
- NCIT_C61070 NCIT_R146 NCIT_C17021 @default.
- NCIT_C61070 NCIT_R146 NCIT_C17728 @default.
- NCIT_C61070 NCIT_R146 NCIT_C20027 @default.
- NCIT_C61070 NCIT_R146 NCIT_C26548 @default.
- NCIT_C61070 NCIT_R146 NCIT_C39592 @default.
- NCIT_C61070 normalizedInformationContent "100" @default.
- NCIT_C61070 referenceCount "1" @default.
- NCIT_C61070 hasExactSynonym "CNTO 095" @default.
- NCIT_C61070 hasExactSynonym "CNTO-95" @default.
- NCIT_C61070 hasExactSynonym "Human Anti-Alpha-5 Integrin Monoclonal Antibody" @default.
- NCIT_C61070 hasExactSynonym "Human Monoclonal CNTO 95 gamma1 heavy chain (222-215')-disulfide with Human Monoclonal CNTO 95 kappa light chain dimer (228-228'':231-231'')-bisdisulfide" @default.
- NCIT_C61070 hasExactSynonym "INTETUMUMAB" @default.
- NCIT_C61070 hasExactSynonym "Immunoglobulin G1, anti-(human integrin alpha-V (vitronectin receptor subunit alpha or CD51))" @default.
- NCIT_C61070 hasExactSynonym "Intetumumab" @default.
- NCIT_C61070 inSubset NCIT_C116977 @default.
- NCIT_C61070 inSubset NCIT_C116978 @default.
- NCIT_C61070 inSubset NCIT_C128784 @default.
- NCIT_C61070 inSubset NCIT_C157711 @default.
- NCIT_C61070 inSubset NCIT_C157712 @default.
- NCIT_C61070 inSubset NCIT_C176424 @default.
- NCIT_C61070 inSubset NCIT_C177537 @default.
- NCIT_C61070 inSubset NCIT_C63923 @default.
- NCIT_C61070 type Class @default.
- NCIT_C61070 isDefinedBy ncit.owl @default.
- NCIT_C61070 label "Intetumumab" @default.
- NCIT_C61070 subClassOf B6560c5954a52967ca6f5170f81206715 @default.
- NCIT_C61070 subClassOf B6922fda8edee53b833e223b1b8496954 @default.
- NCIT_C61070 subClassOf NCIT_C129821 @default.
- NCIT_C61070 subClassOf NCIT_C129822 @default.
- NCIT_C61070 subClassOf NCIT_C1742 @default.
- NCIT_C61070 subClassOf NCIT_C1908 @default.
- NCIT_C61070 subClassOf NCIT_C1909 @default.
- NCIT_C61070 subClassOf NCIT_C20401 @default.
- NCIT_C61070 subClassOf NCIT_C274 @default.
- NCIT_C61070 subClassOf NCIT_C307 @default.
- NCIT_C61070 subClassOf NCIT_C308 @default.
- NCIT_C61070 subClassOf NCIT_C61070 @default.