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- NCIT_C61082 IAO_0000115 "A cancer vaccine comprised of irradiated allogeneic pancreatic cancer cells transfected to express murine alpha-1,3-galactosyltransferase with potential antitumor activity. Vaccination is associated with the expression of murine alpha-1,3-galactosyl (alpha-gal) carbohydrate residues on cell membrane glycoproteins and glycolipids of the vaccine pancreatic cancer cell allograft; murine alpha-gal epitopes, not present on human cells, then induce a hyperacute rejection of the vaccine pancreatic cancer cell allograft. The hyperacute rejection involves the binding of pre-existing human anti-alpha-gal antibodies (which naturally occur against gut flora) to murine alpha-gal epitopes, resulting in the rapid activation of antibody-dependent cell-mediated cytotoxicity (ADCC) towards allograft cells. The host immune system then attacks endogenous pancreatic cancer cells, resulting in ADCC towards endogenous pancreatic cancer cells." @default.
- NCIT_C61082 NCIT_A32 NCIT_C1909 @default.
- NCIT_C61082 NCIT_NHC0 "C61082" @default.
- NCIT_C61082 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61082 NCIT_P107 "Algenpantucel-L" @default.
- NCIT_C61082 NCIT_P108 "Algenpantucel-L" @default.
- NCIT_C61082 NCIT_P207 "C1831790" @default.
- NCIT_C61082 NCIT_P319 "I6HAD3HP89" @default.
- NCIT_C61082 NCIT_P322 "CTRP" @default.
- NCIT_C61082 NCIT_P322 "FDA" @default.
- NCIT_C61082 NCIT_P322 "GDC" @default.
- NCIT_C61082 NCIT_P329 "475734" @default.
- NCIT_C61082 NCIT_P330 "475734" @default.
- NCIT_C61082 NCIT_P366 "Alpha-Gal_Pancreatic_Cancer_Vaccine" @default.
- NCIT_C61082 NCIT_P375 "Algenpantucel-L" @default.
- NCIT_C61082 NCIT_P399 "475734" @default.
- NCIT_C61082 normalizedInformationContent "100" @default.
- NCIT_C61082 referenceCount "1" @default.
- NCIT_C61082 hasExactSynonym "ALGENPANTUCEL-L" @default.
- NCIT_C61082 hasExactSynonym "Algenpantucel-L" @default.
- NCIT_C61082 hasExactSynonym "Alpha (1,3) Galactosyltransferase Tumor Vaccine" @default.
- NCIT_C61082 hasExactSynonym "Alpha-1,3-Galactosyltransferase-expressing Allogeneic Pancreatic Tumor Cell Vaccine" @default.
- NCIT_C61082 hasExactSynonym "HAPa" @default.
- NCIT_C61082 hasExactSynonym "HyperAcute-Pancreas Immunotherapy" @default.
- NCIT_C61082 hasExactSynonym "Hyperacute Pancreatic Cancer Vaccine" @default.
- NCIT_C61082 inSubset NCIT_C116977 @default.
- NCIT_C61082 inSubset NCIT_C116978 @default.
- NCIT_C61082 inSubset NCIT_C128784 @default.
- NCIT_C61082 inSubset NCIT_C157711 @default.
- NCIT_C61082 inSubset NCIT_C157712 @default.
- NCIT_C61082 inSubset NCIT_C176424 @default.
- NCIT_C61082 inSubset NCIT_C177537 @default.
- NCIT_C61082 inSubset NCIT_C63923 @default.
- NCIT_C61082 type Class @default.
- NCIT_C61082 isDefinedBy ncit.owl @default.
- NCIT_C61082 label "Algenpantucel-L" @default.
- NCIT_C61082 subClassOf NCIT_C129820 @default.
- NCIT_C61082 subClassOf NCIT_C129821 @default.
- NCIT_C61082 subClassOf NCIT_C129826 @default.
- NCIT_C61082 subClassOf NCIT_C142078 @default.
- NCIT_C61082 subClassOf NCIT_C1663 @default.
- NCIT_C61082 subClassOf NCIT_C1908 @default.
- NCIT_C61082 subClassOf NCIT_C1909 @default.
- NCIT_C61082 subClassOf NCIT_C1983 @default.
- NCIT_C61082 subClassOf NCIT_C2341 @default.
- NCIT_C61082 subClassOf NCIT_C274 @default.
- NCIT_C61082 subClassOf NCIT_C307 @default.
- NCIT_C61082 subClassOf NCIT_C308 @default.
- NCIT_C61082 subClassOf NCIT_C61082 @default.
- NCIT_C61082 subClassOf NCIT_C923 @default.