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- NCIT_C61084 IAO_0000115 "A chimeric, human-murine, monoclonal antibody targeting the pro-inflammatory cytokine interleukin 6 (IL-6), with antitumor and anti-inflammatory activities. Upon intravenous administration of siltuximab, this agent targets and binds to IL-6. This inhibits the binding of IL-6 to the IL-6 receptor (IL-6R), which results in the blockade of the IL-6/IL-6R-mediated signal transduction pathway. This inhibits cancer cell growth in tumors overexpressing IL-6." @default.
- NCIT_C61084 NCIT_A32 NCIT_C1909 @default.
- NCIT_C61084 NCIT_A7 NCIT_C20451 @default.
- NCIT_C61084 NCIT_NHC0 "C61084" @default.
- NCIT_C61084 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C61084 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61084 NCIT_P107 "Siltuximab" @default.
- NCIT_C61084 NCIT_P108 "Siltuximab" @default.
- NCIT_C61084 NCIT_P208 "CL776663" @default.
- NCIT_C61084 NCIT_P210 "541502-14-1" @default.
- NCIT_C61084 NCIT_P302 "multicentric Castleman's disease (MCD)" @default.
- NCIT_C61084 NCIT_P319 "T4H8FMA7IM" @default.
- NCIT_C61084 NCIT_P322 "CTRP" @default.
- NCIT_C61084 NCIT_P322 "FDA" @default.
- NCIT_C61084 NCIT_P322 "GDC" @default.
- NCIT_C61084 NCIT_P325 "A chimeric (made from human and mouse proteins) monoclonal antibody being studied in the treatment of advanced kidney cancer and other types of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. Anti-IL-6 chimeric monoclonal antibody works by blocking inflammation and tumor growth." @default.
- NCIT_C61084 NCIT_P329 "475765" @default.
- NCIT_C61084 NCIT_P330 "475765" @default.
- NCIT_C61084 NCIT_P366 "Anti-IL-6_Chimeric_Monoclonal_Antibody" @default.
- NCIT_C61084 NCIT_P375 "Siltuximab" @default.
- NCIT_C61084 NCIT_P399 "475765" @default.
- NCIT_C61084 NCIT_R124 NCIT_C17710 @default.
- NCIT_C61084 NCIT_R124 NCIT_C17828 @default.
- NCIT_C61084 NCIT_R124 NCIT_C18219 @default.
- NCIT_C61084 NCIT_R124 NCIT_C19986 @default.
- NCIT_C61084 NCIT_R124 NCIT_C40474 @default.
- NCIT_C61084 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C61084 referenceCount "2" @default.
- NCIT_C61084 hasExactSynonym "Anti-IL-6 Chimeric Monoclonal Antibody" @default.
- NCIT_C61084 hasExactSynonym "CNTO 328" @default.
- NCIT_C61084 hasExactSynonym "CNTO-328" @default.
- NCIT_C61084 hasExactSynonym "SILTUXIMAB" @default.
- NCIT_C61084 hasExactSynonym "Siltuximab" @default.
- NCIT_C61084 hasExactSynonym "Sylvant" @default.
- NCIT_C61084 hasExactSynonym "anti-IL-6 chimeric monoclonal antibody" @default.
- NCIT_C61084 hasExactSynonym "cCLB8" @default.
- NCIT_C61084 inSubset NCIT_C116977 @default.
- NCIT_C61084 inSubset NCIT_C116978 @default.
- NCIT_C61084 inSubset NCIT_C128784 @default.
- NCIT_C61084 inSubset NCIT_C157711 @default.
- NCIT_C61084 inSubset NCIT_C157712 @default.
- NCIT_C61084 inSubset NCIT_C173381 @default.
- NCIT_C61084 inSubset NCIT_C173383 @default.
- NCIT_C61084 inSubset NCIT_C176424 @default.
- NCIT_C61084 inSubset NCIT_C177537 @default.
- NCIT_C61084 inSubset NCIT_C63923 @default.
- NCIT_C61084 type Class @default.
- NCIT_C61084 isDefinedBy ncit.owl @default.
- NCIT_C61084 label "Siltuximab" @default.
- NCIT_C61084 subClassOf NCIT_C129821 @default.
- NCIT_C61084 subClassOf NCIT_C129822 @default.
- NCIT_C61084 subClassOf NCIT_C163951 @default.
- NCIT_C61084 subClassOf NCIT_C1908 @default.
- NCIT_C61084 subClassOf NCIT_C1909 @default.
- NCIT_C61084 subClassOf NCIT_C20401 @default.
- NCIT_C61084 subClassOf NCIT_C274 @default.
- NCIT_C61084 subClassOf NCIT_C307 @default.
- NCIT_C61084 subClassOf NCIT_C308 @default.
- NCIT_C61084 subClassOf NCIT_C61084 @default.