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- NCIT_C61304 IAO_0000115 "A folate-based biomodulator with potential antineoplastic activity. 5,10-methylenetetrahydrofolate (MTHF) stabilizes the covalent binding of the fluorouracil metabolite 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (FdUMP) to its target enzyme, thymidylate synthase, which results in inhibition of thymidylate synthase, depletion of thymidine triphosphate (TTP), a necessary constituent of DNA, and tumor cell death. Unlike leucovorin, MTHF, as the active form of folate, does not require metabolic activation and may increase the chemotherapeutic effects of fluorouracil with lower toxicity." @default.
- NCIT_C61304 NCIT_A32 NCIT_C1909 @default.
- NCIT_C61304 NCIT_NHC0 "C61304" @default.
- NCIT_C61304 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61304 NCIT_P108 "Folitixorin" @default.
- NCIT_C61304 NCIT_P207 "C0048858" @default.
- NCIT_C61304 NCIT_P210 "3432-99-3" @default.
- NCIT_C61304 NCIT_P319 "0SXY5ET48B" @default.
- NCIT_C61304 NCIT_P322 "FDA" @default.
- NCIT_C61304 NCIT_P322 "GDC" @default.
- NCIT_C61304 NCIT_P329 "405875" @default.
- NCIT_C61304 NCIT_P330 "405875" @default.
- NCIT_C61304 NCIT_P350 "C20H23N7O6" @default.
- NCIT_C61304 NCIT_P366 "_5_10-Methylenetetrahydrofolate" @default.
- NCIT_C61304 NCIT_P368 "CHEBI:1989" @default.
- NCIT_C61304 NCIT_P375 "Folitixorin" @default.
- NCIT_C61304 NCIT_P399 "405875" @default.
- NCIT_C61304 normalizedInformationContent "100" @default.
- NCIT_C61304 referenceCount "1" @default.
- NCIT_C61304 hasExactSynonym "5,10-Methylenetetrahydrofolate" @default.
- NCIT_C61304 hasExactSynonym "5,10-methylene-5,6,7,8-tetrahydrofolic Acid" @default.
- NCIT_C61304 hasExactSynonym "CoFactor" @default.
- NCIT_C61304 hasExactSynonym "FOLITIXORIN" @default.
- NCIT_C61304 hasExactSynonym "Folitixorin" @default.
- NCIT_C61304 hasExactSynonym "N-(4-(3-Amino-1,2,5,6,6a,7-hexahydro-1-oxoimidazo(1,5-f)pteridin-8(9H)-yl)benzoyl)-L-glutamic Acid" @default.
- NCIT_C61304 hasExactSynonym "Tetrahydromethylenefolate" @default.
- NCIT_C61304 inSubset NCIT_C128784 @default.
- NCIT_C61304 inSubset NCIT_C157711 @default.
- NCIT_C61304 inSubset NCIT_C157712 @default.
- NCIT_C61304 inSubset NCIT_C176424 @default.
- NCIT_C61304 inSubset NCIT_C177537 @default.
- NCIT_C61304 inSubset NCIT_C63923 @default.
- NCIT_C61304 type Class @default.
- NCIT_C61304 isDefinedBy ncit.owl @default.
- NCIT_C61304 label "Folitixorin" @default.
- NCIT_C61304 subClassOf NCIT_C1908 @default.
- NCIT_C61304 subClassOf NCIT_C1909 @default.
- NCIT_C61304 subClassOf NCIT_C2078 @default.
- NCIT_C61304 subClassOf NCIT_C2140 @default.
- NCIT_C61304 subClassOf NCIT_C61304 @default.