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- NCIT_C61307 IAO_0000115 "A fusion protein immunotoxin consisting of a humanized, single-chain monoclonal antibody fragment specific for the epithelial cell adhesion molecule (EpCAM) conjugated with a truncated form of Pseudomonas exotoxin A with potential antineoplastic activity. Oportuzumab monatox binds to Ep-CAM-positive tumor cells, thereby delivering the Pseudomonas exotoxin A moiety specifically; the Pseudomonas exotoxin A moiety then inactivates elongation factor 2 (EF-2) through ADP ribosylation, resulting in inhibition of protein synthesis in target cells. EpCAM, a cell surface protein, is expressed by a variety of tumor cells and is frequently found in head and neck cancers." @default.
- NCIT_C61307 NCIT_A32 NCIT_C1909 @default.
- NCIT_C61307 NCIT_A7 NCIT_C20209 @default.
- NCIT_C61307 NCIT_NHC0 "C61307" @default.
- NCIT_C61307 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61307 NCIT_P107 "Oportuzumab Monatox" @default.
- NCIT_C61307 NCIT_P108 "Oportuzumab Monatox" @default.
- NCIT_C61307 NCIT_P207 "C1831819" @default.
- NCIT_C61307 NCIT_P210 "945228-48-8" @default.
- NCIT_C61307 NCIT_P302 "advanced, recurrent head and neck cancer" @default.
- NCIT_C61307 NCIT_P319 "945CY7ZMI2" @default.
- NCIT_C61307 NCIT_P322 "CTRP" @default.
- NCIT_C61307 NCIT_P322 "FDA" @default.
- NCIT_C61307 NCIT_P322 "GDC" @default.
- NCIT_C61307 NCIT_P325 "A substance being studied in the treatment of certain types of head and neck cancer. Anti-EpCAM-Pseudomonas-exotoxin fusion protein is made by linking a monoclonal antibody fragment to a toxic protein that may kill cancer cells. It binds to EpCAM (a protein on the surface of epithelial cells and some types of cancer cells)." @default.
- NCIT_C61307 NCIT_P329 "485164" @default.
- NCIT_C61307 NCIT_P330 "485164" @default.
- NCIT_C61307 NCIT_P366 "Anti-EpCAM-Pseudomonas-exotoxin_Fusion_Protein" @default.
- NCIT_C61307 NCIT_P375 "Oportuzumab Monatox" @default.
- NCIT_C61307 NCIT_P399 "485164" @default.
- NCIT_C61307 normalizedInformationContent "100" @default.
- NCIT_C61307 referenceCount "1" @default.
- NCIT_C61307 hasExactSynonym "OPORTUZUMAB MONATOX" @default.
- NCIT_C61307 hasExactSynonym "Oportuzumab Monatox" @default.
- NCIT_C61307 hasExactSynonym "Proxinium" @default.
- NCIT_C61307 hasExactSynonym "VB4 845" @default.
- NCIT_C61307 hasExactSynonym "VB4-845" @default.
- NCIT_C61307 hasExactSynonym "Vicinium" @default.
- NCIT_C61307 hasExactSynonym "anti-EpCAM-Pseudomonas-exotoxin fusion protein" @default.
- NCIT_C61307 inSubset NCIT_C116977 @default.
- NCIT_C61307 inSubset NCIT_C116978 @default.
- NCIT_C61307 inSubset NCIT_C128784 @default.
- NCIT_C61307 inSubset NCIT_C157711 @default.
- NCIT_C61307 inSubset NCIT_C157712 @default.
- NCIT_C61307 inSubset NCIT_C176424 @default.
- NCIT_C61307 inSubset NCIT_C177537 @default.
- NCIT_C61307 inSubset NCIT_C63923 @default.
- NCIT_C61307 type Class @default.
- NCIT_C61307 isDefinedBy ncit.owl @default.
- NCIT_C61307 label "Oportuzumab Monatox" @default.
- NCIT_C61307 subClassOf NCIT_C1512 @default.
- NCIT_C61307 subClassOf NCIT_C1908 @default.
- NCIT_C61307 subClassOf NCIT_C1909 @default.
- NCIT_C61307 subClassOf NCIT_C307 @default.
- NCIT_C61307 subClassOf NCIT_C308 @default.
- NCIT_C61307 subClassOf NCIT_C575 @default.
- NCIT_C61307 subClassOf NCIT_C61307 @default.