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- NCIT_C61311 IAO_0000115 "An orally bioavailable small molecule with potential antineoplastic activity. CHIR-265 binds and inhibits Raf kinases, which may result in a reduction of tumor cell growth and proliferation, and tumor cell death. In addition, this agent inhibits vascular endothelial growth factor receptor type 2 (VEGFR-2), thereby disrupting tumor angiogenesis. Raf kinases are critical enzymes in the Ras/Raf/MEK/ERK signaling pathway and are frequently upregulated in neoplasms." @default.
- NCIT_C61311 NCIT_A32 NCIT_C1909 @default.
- NCIT_C61311 NCIT_A7 NCIT_C17476 @default.
- NCIT_C61311 NCIT_A7 NCIT_C17484 @default.
- NCIT_C61311 NCIT_A7 NCIT_C28496 @default.
- NCIT_C61311 NCIT_NHC0 "C61311" @default.
- NCIT_C61311 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61311 NCIT_P107 "B-Raf/VEGFR-2 Inhibitor RAF265" @default.
- NCIT_C61311 NCIT_P108 "B-Raf/VEGFR-2 Inhibitor RAF265" @default.
- NCIT_C61311 NCIT_P207 "C1831810" @default.
- NCIT_C61311 NCIT_P210 "927880-90-8" @default.
- NCIT_C61311 NCIT_P319 "8O434L3768" @default.
- NCIT_C61311 NCIT_P322 "CTRP" @default.
- NCIT_C61311 NCIT_P322 "FDA" @default.
- NCIT_C61311 NCIT_P322 "GDC" @default.
- NCIT_C61311 NCIT_P325 "A substance being studied in the treatment of melanoma. CHIR-265 may block the growth of tumors and the growth of blood vessels from surrounding tissue to the tumor. It is a type of Raf kinase inhibitor and angiogenesis inhibitor." @default.
- NCIT_C61311 NCIT_P329 "484456" @default.
- NCIT_C61311 NCIT_P330 "484456" @default.
- NCIT_C61311 NCIT_P366 "CHIR-265" @default.
- NCIT_C61311 NCIT_P375 "B-Raf/VEGFR-2 Inhibitor RAF265" @default.
- NCIT_C61311 NCIT_P399 "484456" @default.
- NCIT_C61311 normalizedInformationContent "100" @default.
- NCIT_C61311 referenceCount "1" @default.
- NCIT_C61311 hasExactSynonym "B-Raf/VEGFR-2 Inhibitor RAF265" @default.
- NCIT_C61311 hasExactSynonym "CHIR-265" @default.
- NCIT_C61311 hasExactSynonym "RAF 265" @default.
- NCIT_C61311 hasExactSynonym "RAF-265" @default.
- NCIT_C61311 hasExactSynonym "RAF265" @default.
- NCIT_C61311 inSubset NCIT_C116977 @default.
- NCIT_C61311 inSubset NCIT_C116978 @default.
- NCIT_C61311 inSubset NCIT_C128784 @default.
- NCIT_C61311 inSubset NCIT_C157711 @default.
- NCIT_C61311 inSubset NCIT_C157712 @default.
- NCIT_C61311 inSubset NCIT_C176424 @default.
- NCIT_C61311 inSubset NCIT_C177537 @default.
- NCIT_C61311 inSubset NCIT_C63923 @default.
- NCIT_C61311 type Class @default.
- NCIT_C61311 isDefinedBy ncit.owl @default.
- NCIT_C61311 label "B-Raf/VEGFR-2 Inhibitor RAF265" @default.
- NCIT_C61311 subClassOf NCIT_C129824 @default.
- NCIT_C61311 subClassOf NCIT_C129825 @default.
- NCIT_C61311 subClassOf NCIT_C1404 @default.
- NCIT_C61311 subClassOf NCIT_C155322 @default.
- NCIT_C61311 subClassOf NCIT_C163758 @default.
- NCIT_C61311 subClassOf NCIT_C163953 @default.
- NCIT_C61311 subClassOf NCIT_C1742 @default.
- NCIT_C61311 subClassOf NCIT_C1908 @default.
- NCIT_C61311 subClassOf NCIT_C1909 @default.
- NCIT_C61311 subClassOf NCIT_C1967 @default.
- NCIT_C61311 subClassOf NCIT_C2189 @default.
- NCIT_C61311 subClassOf NCIT_C2336 @default.
- NCIT_C61311 subClassOf NCIT_C274 @default.
- NCIT_C61311 subClassOf NCIT_C471 @default.
- NCIT_C61311 subClassOf NCIT_C61074 @default.
- NCIT_C61311 subClassOf NCIT_C61311 @default.
- NCIT_C61311 subClassOf NCIT_C93259 @default.