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- NCIT_C61313 IAO_0000115 "A fully human monoclonal antibody directed against the receptor activator of nuclear factor kappa beta ligand (RANKL) with antiosteoclast activity. Denosumab specifically binds to RANKL and blocks the interaction of RANKL with RANK, a receptor located on osteoclast cell surfaces, resulting in inhibition of osteoclast activity, a decrease in bone resorption, and a potential increase in bone mineral density. RANKL, a protein expressed by osteoblastic cells, plays an important role in osteoclastic differentiation and activation." @default.
- NCIT_C61313 NCIT_A32 NCIT_C1909 @default.
- NCIT_C61313 NCIT_A7 NCIT_C30113 @default.
- NCIT_C61313 NCIT_NHC0 "C61313" @default.
- NCIT_C61313 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61313 NCIT_P107 "Denosumab" @default.
- NCIT_C61313 NCIT_P108 "Denosumab" @default.
- NCIT_C61313 NCIT_P207 "C1690432" @default.
- NCIT_C61313 NCIT_P210 "615258-40-7" @default.
- NCIT_C61313 NCIT_P302 "Osteolytic Bone Metastases of Solid Tumors" @default.
- NCIT_C61313 NCIT_P319 "4EQZ6YO2HI" @default.
- NCIT_C61313 NCIT_P322 "CTRP" @default.
- NCIT_C61313 NCIT_P322 "FDA" @default.
- NCIT_C61313 NCIT_P322 "GDC" @default.
- NCIT_C61313 NCIT_P322 "PCDC" @default.
- NCIT_C61313 NCIT_P325 "A type of monoclonal antibody being studied in the treatment of multiple myeloma (a cancer that forms in bones) and in the prevention and treatment of bone metastases (cancer that has spread to bone from another organ). Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. AMG 162 binds to the protein RANKL and helps keep bone from breaking down." @default.
- NCIT_C61313 NCIT_P329 "481348" @default.
- NCIT_C61313 NCIT_P330 "481348" @default.
- NCIT_C61313 NCIT_P366 "Densosumab" @default.
- NCIT_C61313 NCIT_P375 "Denosumab" @default.
- NCIT_C61313 NCIT_P399 "481348" @default.
- NCIT_C61313 NCIT_R124 NCIT_C17710 @default.
- NCIT_C61313 NCIT_R124 NCIT_C17828 @default.
- NCIT_C61313 NCIT_R124 NCIT_C18219 @default.
- NCIT_C61313 NCIT_R124 NCIT_C19986 @default.
- NCIT_C61313 NCIT_R124 NCIT_C40474 @default.
- NCIT_C61313 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C61313 referenceCount "2" @default.
- NCIT_C61313 hasExactSynonym "AMG 162" @default.
- NCIT_C61313 hasExactSynonym "AMG-162" @default.
- NCIT_C61313 hasExactSynonym "DENOSUMAB" @default.
- NCIT_C61313 hasExactSynonym "Denosumab Biosimilar MW032" @default.
- NCIT_C61313 hasExactSynonym "Denosumab Biosimilar QL1206" @default.
- NCIT_C61313 hasExactSynonym "Denosumab Biosimilar TK-006" @default.
- NCIT_C61313 hasExactSynonym "Denosumab" @default.
- NCIT_C61313 hasExactSynonym "Prolia" @default.
- NCIT_C61313 hasExactSynonym "TK-006" @default.
- NCIT_C61313 hasExactSynonym "Xgeva" @default.
- NCIT_C61313 hasExactSynonym "denosumab" @default.
- NCIT_C61313 inSubset NCIT_C116977 @default.
- NCIT_C61313 inSubset NCIT_C116978 @default.
- NCIT_C61313 inSubset NCIT_C128784 @default.
- NCIT_C61313 inSubset NCIT_C157711 @default.
- NCIT_C61313 inSubset NCIT_C157712 @default.
- NCIT_C61313 inSubset NCIT_C176424 @default.
- NCIT_C61313 inSubset NCIT_C177537 @default.
- NCIT_C61313 inSubset NCIT_C179478 @default.
- NCIT_C61313 inSubset NCIT_C179531 @default.
- NCIT_C61313 inSubset NCIT_C63923 @default.
- NCIT_C61313 type Class @default.
- NCIT_C61313 isDefinedBy ncit.owl @default.
- NCIT_C61313 label "Denosumab" @default.
- NCIT_C61313 subClassOf NCIT_C129821 @default.
- NCIT_C61313 subClassOf NCIT_C129822 @default.
- NCIT_C61313 subClassOf NCIT_C1908 @default.
- NCIT_C61313 subClassOf NCIT_C1909 @default.
- NCIT_C61313 subClassOf NCIT_C20401 @default.
- NCIT_C61313 subClassOf NCIT_C274 @default.
- NCIT_C61313 subClassOf NCIT_C307 @default.
- NCIT_C61313 subClassOf NCIT_C308 @default.
- NCIT_C61313 subClassOf NCIT_C61313 @default.