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- NCIT_C61314 IAO_0000115 "An ICP34.5, ICP47-deleted, oncolytic herpes simplex type-1 virus (HSV-1) based on the JS1 strain, and encoding the immunostimulating factor human cytokine granulocyte-macrophage colony stimulating factor (GM-CSF) with potential immunostimulating and antineoplastic activities. Upon intratumoral injection, talimogene laherparepvec selectively infects and replicates in tumor cells, thereby inducing tumor cell lysis. In addition, GM-CSF attracts dendritic cells (DCs) and may stimulate a cytotoxic T cell response against tumor cells, which results in immune-mediated tumor cell death. Deletion of the gene encoding for ICP34.5 provides tumor selectivity and prevents replication in healthy cells. As ICP47 blocks antigen presentation in HSV-infected cells, deletion of this gene may induce a more potent antitumor immune response in the tumor cells. Additionally, deletion of ICP47 causes increased expression of the HSV US11 gene and allows US11 to be expressed as an immediate early and not a late gene. This further enhances the degree of viral replication and oncolysis of tumor cells." @default.
- NCIT_C61314 NCIT_A32 NCIT_C1909 @default.
- NCIT_C61314 NCIT_NHC0 "C61314" @default.
- NCIT_C61314 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61314 NCIT_P107 "Talimogene Laherparepvec" @default.
- NCIT_C61314 NCIT_P108 "Talimogene Laherparepvec" @default.
- NCIT_C61314 NCIT_P207 "C1831828" @default.
- NCIT_C61314 NCIT_P210 "1187560-31-1" @default.
- NCIT_C61314 NCIT_P302 "local treatment of unresectable cutaneous, subcutaneous, and nodal lesions in patients with melanoma recurrent after initial surgery" @default.
- NCIT_C61314 NCIT_P319 "07730V90L6" @default.
- NCIT_C61314 NCIT_P322 "CTRP" @default.
- NCIT_C61314 NCIT_P322 "FDA" @default.
- NCIT_C61314 NCIT_P322 "GDC" @default.
- NCIT_C61314 NCIT_P329 "485296" @default.
- NCIT_C61314 NCIT_P330 "485296" @default.
- NCIT_C61314 NCIT_P366 "GM-CSF-Encoding_Oncolytic_Herpes_Simplex_Virus_Vaccine" @default.
- NCIT_C61314 NCIT_P375 "Talimogene Laherparepvec" @default.
- NCIT_C61314 NCIT_P399 "485296" @default.
- NCIT_C61314 normalizedInformationContent "92.730304365937428" @default.
- NCIT_C61314 referenceCount "3" @default.
- NCIT_C61314 hasExactSynonym "ICP34.5-, ICP47-deleted Herpes Simplex Virus 1 (HSV-1) Incorporating the Human GM-CSF Gene" @default.
- NCIT_C61314 hasExactSynonym "Imlygic" @default.
- NCIT_C61314 hasExactSynonym "JS1 34.5-hGMCSF 47- pA-" @default.
- NCIT_C61314 hasExactSynonym "OncoVEX GM-CSF" @default.
- NCIT_C61314 hasExactSynonym "T-VEC" @default.
- NCIT_C61314 hasExactSynonym "TALIMOGENE LAHERPAREPVEC" @default.
- NCIT_C61314 hasExactSynonym "Talimogene Laherparepvec" @default.
- NCIT_C61314 inSubset NCIT_C116977 @default.
- NCIT_C61314 inSubset NCIT_C116978 @default.
- NCIT_C61314 inSubset NCIT_C128784 @default.
- NCIT_C61314 inSubset NCIT_C157711 @default.
- NCIT_C61314 inSubset NCIT_C157712 @default.
- NCIT_C61314 inSubset NCIT_C176424 @default.
- NCIT_C61314 inSubset NCIT_C177537 @default.
- NCIT_C61314 inSubset NCIT_C63923 @default.
- NCIT_C61314 type Class @default.
- NCIT_C61314 isDefinedBy ncit.owl @default.
- NCIT_C61314 label "Talimogene Laherparepvec" @default.
- NCIT_C61314 subClassOf NCIT_C129821 @default.
- NCIT_C61314 subClassOf NCIT_C1908 @default.
- NCIT_C61314 subClassOf NCIT_C1909 @default.
- NCIT_C61314 subClassOf NCIT_C1962 @default.
- NCIT_C61314 subClassOf NCIT_C2139 @default.
- NCIT_C61314 subClassOf NCIT_C274 @default.
- NCIT_C61314 subClassOf NCIT_C307 @default.
- NCIT_C61314 subClassOf NCIT_C308 @default.
- NCIT_C61314 subClassOf NCIT_C61314 @default.
- NCIT_C61314 subClassOf NCIT_C717 @default.