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- NCIT_C61315 IAO_0000115 "A isoindolinone derivative and potent inhibitor of the nuclear enzyme poly (ADP-ribose) polymerase (PARP) with chemosensitization and radiosensitization properties. INO-1001 inhibits PARP, which may result in inhibition of tumor cell DNA repair mechanisms and, so, tumor cell resistance to chemotherapy and radiation therapy. PARP enzymes are activated by DNA breaks and have been implicated in the repair of DNA single-strand breaks (SSB)." @default.
- NCIT_C61315 NCIT_A32 NCIT_C1909 @default.
- NCIT_C61315 NCIT_NHC0 "C61315" @default.
- NCIT_C61315 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61315 NCIT_P108 "INO-1001" @default.
- NCIT_C61315 NCIT_P207 "C1504945" @default.
- NCIT_C61315 NCIT_P210 "624747-02-0" @default.
- NCIT_C61315 NCIT_P319 "55E08EN074" @default.
- NCIT_C61315 NCIT_P322 "FDA" @default.
- NCIT_C61315 NCIT_P322 "GDC" @default.
- NCIT_C61315 NCIT_P329 "485165" @default.
- NCIT_C61315 NCIT_P330 "485165" @default.
- NCIT_C61315 NCIT_P366 "INO-1001" @default.
- NCIT_C61315 NCIT_P375 "INO-1001" @default.
- NCIT_C61315 NCIT_P399 "485165" @default.
- NCIT_C61315 NCIT_R146 NCIT_C104101 @default.
- NCIT_C61315 NCIT_R146 NCIT_C16554 @default.
- NCIT_C61315 NCIT_R146 NCIT_C17021 @default.
- NCIT_C61315 NCIT_R146 NCIT_C17210 @default.
- NCIT_C61315 NCIT_R146 NCIT_C17434 @default.
- NCIT_C61315 NCIT_R146 NCIT_C20027 @default.
- NCIT_C61315 NCIT_R146 NCIT_C21170 @default.
- NCIT_C61315 NCIT_R146 NCIT_C26548 @default.
- NCIT_C61315 NCIT_R146 NCIT_C48215 @default.
- NCIT_C61315 normalizedInformationContent "100" @default.
- NCIT_C61315 referenceCount "1" @default.
- NCIT_C61315 hasExactSynonym "INO 1001" @default.
- NCIT_C61315 hasExactSynonym "INO-1001" @default.
- NCIT_C61315 inSubset NCIT_C128784 @default.
- NCIT_C61315 inSubset NCIT_C157711 @default.
- NCIT_C61315 inSubset NCIT_C157712 @default.
- NCIT_C61315 inSubset NCIT_C176424 @default.
- NCIT_C61315 inSubset NCIT_C177537 @default.
- NCIT_C61315 inSubset NCIT_C63923 @default.
- NCIT_C61315 type Class @default.
- NCIT_C61315 isDefinedBy ncit.owl @default.
- NCIT_C61315 label "INO-1001" @default.
- NCIT_C61315 subClassOf NCIT_C163758 @default.
- NCIT_C61315 subClassOf NCIT_C1908 @default.
- NCIT_C61315 subClassOf NCIT_C1909 @default.
- NCIT_C61315 subClassOf NCIT_C274 @default.
- NCIT_C61315 subClassOf NCIT_C471 @default.
- NCIT_C61315 subClassOf NCIT_C61315 @default.
- NCIT_C61315 subClassOf NCIT_C62554 @default.