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- NCIT_C61318 IAO_0000115 "A sulfonamide derivate and carbonic anhydrase inhibitor with potential antineoplastic activity. Methazolamide inhibits tumor-associated carbonic anhydrase IX (CAIX), which may result in increased cell death in hypoxic tumors. As a hypoxia-inducible transmembrane glycoprotein, CAIX catalyzes the rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions, helping to maintain acidification of the tumor microenvironment and enhance resistance to cytotoxic therapy in some hypoxic tumors." @default.
- NCIT_C61318 NCIT_A32 NCIT_C1909 @default.
- NCIT_C61318 NCIT_NHC0 "C61318" @default.
- NCIT_C61318 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61318 NCIT_P108 "Methazolamide" @default.
- NCIT_C61318 NCIT_P207 "C0025631" @default.
- NCIT_C61318 NCIT_P210 "554-57-4" @default.
- NCIT_C61318 NCIT_P319 "W733B0S9SD" @default.
- NCIT_C61318 NCIT_P322 "FDA" @default.
- NCIT_C61318 NCIT_P322 "GDC" @default.
- NCIT_C61318 NCIT_P329 "484587" @default.
- NCIT_C61318 NCIT_P330 "484587" @default.
- NCIT_C61318 NCIT_P350 "C5H8N4O3S2" @default.
- NCIT_C61318 NCIT_P366 "Methazolamide" @default.
- NCIT_C61318 NCIT_P375 "Methazolamide" @default.
- NCIT_C61318 NCIT_P399 "484587" @default.
- NCIT_C61318 normalizedInformationContent "100" @default.
- NCIT_C61318 referenceCount "1" @default.
- NCIT_C61318 hasExactSynonym "Glauctabs" @default.
- NCIT_C61318 hasExactSynonym "METHAZOLAMIDE" @default.
- NCIT_C61318 hasExactSynonym "MZM" @default.
- NCIT_C61318 hasExactSynonym "Methazolamide" @default.
- NCIT_C61318 hasExactSynonym "N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]-acetamide" @default.
- NCIT_C61318 hasExactSynonym "Neptazane" @default.
- NCIT_C61318 inSubset NCIT_C128784 @default.
- NCIT_C61318 inSubset NCIT_C157711 @default.
- NCIT_C61318 inSubset NCIT_C157712 @default.
- NCIT_C61318 inSubset NCIT_C176424 @default.
- NCIT_C61318 inSubset NCIT_C177537 @default.
- NCIT_C61318 inSubset NCIT_C63923 @default.
- NCIT_C61318 type Class @default.
- NCIT_C61318 isDefinedBy ncit.owl @default.
- NCIT_C61318 label "Methazolamide" @default.
- NCIT_C61318 subClassOf NCIT_C1908 @default.
- NCIT_C61318 subClassOf NCIT_C1909 @default.
- NCIT_C61318 subClassOf NCIT_C29577 @default.
- NCIT_C61318 subClassOf NCIT_C448 @default.
- NCIT_C61318 subClassOf NCIT_C471 @default.
- NCIT_C61318 subClassOf NCIT_C61318 @default.
- NCIT_C61318 subClassOf NCIT_C78275 @default.