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- NCIT_C61440 IAO_0000115 "A transdermal formulation containing the synthetic form of estradiol, the most potent, endogenously produced estrogen. Upon topical administration, estradiol diffuses through the cell membrane and binds to and activates specific intracellular estrogen receptors located on estrogen-responsive tissues, including the reproductive tract, breast, pituitary, hypothalamus, liver, and bone. The activated ligand-receptor complex binds to estrogen response elements on DNA and promotes the transcription of genes involved in the functioning of the female reproductive system and secondary sex characteristics. In addition, estradiol inhibits the pituitary secretion of the gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH) through a negative feedback mechanism." @default.
- NCIT_C61440 NCIT_NHC0 "C61440" @default.
- NCIT_C61440 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61440 NCIT_P108 "Transdermal Estrogen" @default.
- NCIT_C61440 NCIT_P207 "C1949350" @default.
- NCIT_C61440 NCIT_P329 "472200" @default.
- NCIT_C61440 NCIT_P330 "472200" @default.
- NCIT_C61440 NCIT_P366 "Transdermal_Estrogen" @default.
- NCIT_C61440 NCIT_P399 "472200" @default.
- NCIT_C61440 NCIT_R122 NCIT_C16484 @default.
- NCIT_C61440 NCIT_R122 NCIT_C16486 @default.
- NCIT_C61440 NCIT_R122 NCIT_C16554 @default.
- NCIT_C61440 NCIT_R122 NCIT_C16865 @default.
- NCIT_C61440 NCIT_R122 NCIT_C16946 @default.
- NCIT_C61440 NCIT_R122 NCIT_C17021 @default.
- NCIT_C61440 NCIT_R122 NCIT_C17573 @default.
- NCIT_C61440 NCIT_R122 NCIT_C17673 @default.
- NCIT_C61440 NCIT_R122 NCIT_C20027 @default.
- NCIT_C61440 NCIT_R122 NCIT_C26548 @default.
- NCIT_C61440 NCIT_R122 NCIT_C28459 @default.
- NCIT_C61440 NCIT_R122 NCIT_C45999 @default.
- NCIT_C61440 NCIT_R122 NCIT_C46000 @default.
- NCIT_C61440 normalizedInformationContent "100" @default.
- NCIT_C61440 referenceCount "1" @default.
- NCIT_C61440 hasExactSynonym "Divigel" @default.
- NCIT_C61440 hasExactSynonym "EstroGel" @default.
- NCIT_C61440 hasExactSynonym "Estrodiol Gel" @default.
- NCIT_C61440 hasExactSynonym "Transdermal Estrogen" @default.
- NCIT_C61440 inSubset NCIT_C176424 @default.
- NCIT_C61440 type Class @default.
- NCIT_C61440 isDefinedBy ncit.owl @default.
- NCIT_C61440 label "Transdermal Estrogen" @default.
- NCIT_C61440 subClassOf NCIT_C147908 @default.
- NCIT_C61440 subClassOf NCIT_C1636 @default.
- NCIT_C61440 subClassOf NCIT_C1908 @default.
- NCIT_C61440 subClassOf NCIT_C1909 @default.
- NCIT_C61440 subClassOf NCIT_C2181 @default.
- NCIT_C61440 subClassOf NCIT_C478 @default.
- NCIT_C61440 subClassOf NCIT_C483 @default.
- NCIT_C61440 subClassOf NCIT_C548 @default.
- NCIT_C61440 subClassOf NCIT_C61440 @default.