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- NCIT_C61499 IAO_0000115 "A nitric oxide (NO) donating derivative of acetylsalicylic acid with anti-inflammatory, analgesic, antipyretic, antithrombotic, gastroprotective and potential antitumor activities. The acetylsalicylic acid derivative moiety of this agent inhibits the activities of cyclooxygenase (COX) I and II, preventing the formation of prostaglandins and thromboxanes. A reduction in prostaglandin synthesis accounts for this agent's anti-inflammatory, anti-pyretic and analgesic activities; a reduction in thromboxane A2 synthesis results in an irreversible inhibition of platelet aggregation. NO donation by this agent, after cleavage from the acetylsalicylic acid derivative in vivo, may protect the gastric mucosa against the damaging effects of the aspirin derivative by modulating prostaglandins. In tumor cells, the NO donating moiety may block the cell cycle in the G1 and G2 phases and may induce apoptosis through caspase-mediated mechanisms." @default.
- NCIT_C61499 NCIT_A32 NCIT_C1909 @default.
- NCIT_C61499 NCIT_NHC0 "C61499" @default.
- NCIT_C61499 NCIT_P106 "Organic Chemical" @default.
- NCIT_C61499 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61499 NCIT_P108 "Nitric Oxide-Releasing Acetylsalicylic Acid Derivative" @default.
- NCIT_C61499 NCIT_P207 "C0531264" @default.
- NCIT_C61499 NCIT_P210 "175033-36-0" @default.
- NCIT_C61499 NCIT_P319 "EH04H13L6B" @default.
- NCIT_C61499 NCIT_P322 "FDA" @default.
- NCIT_C61499 NCIT_P322 "GDC" @default.
- NCIT_C61499 NCIT_P325 "A substance being studied in the prevention of colorectal cancer. It is a form of aspirin that gives off nitric oxide gas and is less irritating to the lining of the stomach than plain aspirin. It is a type of nonsteroidal anti-inflammatory drug (NSAID)." @default.
- NCIT_C61499 NCIT_P329 "486415" @default.
- NCIT_C61499 NCIT_P330 "486415" @default.
- NCIT_C61499 NCIT_P366 "Nitric_Oxide-Releasing_Acetylsalicylic_Acid_Derivative" @default.
- NCIT_C61499 NCIT_P375 "Nitric Oxide-Releasing Acetylsalicylic Acid Derivative" @default.
- NCIT_C61499 NCIT_P399 "486415" @default.
- NCIT_C61499 normalizedInformationContent "100" @default.
- NCIT_C61499 referenceCount "1" @default.
- NCIT_C61499 hasExactSynonym "Benzoic Acid, 2-(Acetyl-oxy)-3-[(nitrooxy)methyl]phenyl Ester" @default.
- NCIT_C61499 hasExactSynonym "NCX 4016" @default.
- NCIT_C61499 hasExactSynonym "NCX-4016" @default.
- NCIT_C61499 hasExactSynonym "Nitric Oxide-Releasing Acetylsalicylic Acid Derivative" @default.
- NCIT_C61499 hasExactSynonym "Nitric Oxide-Releasing Aspirin Derivative" @default.
- NCIT_C61499 hasExactSynonym "Nitroaspirin" @default.
- NCIT_C61499 hasExactSynonym "nitric oxide-releasing acetylsalicylic acid derivative" @default.
- NCIT_C61499 inSubset NCIT_C128784 @default.
- NCIT_C61499 inSubset NCIT_C157711 @default.
- NCIT_C61499 inSubset NCIT_C157712 @default.
- NCIT_C61499 inSubset NCIT_C176424 @default.
- NCIT_C61499 inSubset NCIT_C177537 @default.
- NCIT_C61499 inSubset NCIT_C63923 @default.
- NCIT_C61499 type Class @default.
- NCIT_C61499 isDefinedBy ncit.owl @default.
- NCIT_C61499 label "Nitric Oxide-Releasing Acetylsalicylic Acid Derivative" @default.
- NCIT_C61499 subClassOf NCIT_C1323 @default.
- NCIT_C61499 subClassOf NCIT_C1908 @default.
- NCIT_C61499 subClassOf NCIT_C1909 @default.
- NCIT_C61499 subClassOf NCIT_C2198 @default.
- NCIT_C61499 subClassOf NCIT_C2356 @default.
- NCIT_C61499 subClassOf NCIT_C241 @default.
- NCIT_C61499 subClassOf NCIT_C257 @default.
- NCIT_C61499 subClassOf NCIT_C45845 @default.
- NCIT_C61499 subClassOf NCIT_C471 @default.
- NCIT_C61499 subClassOf NCIT_C61499 @default.
- NCIT_C61499 subClassOf NCIT_C78272 @default.