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- NCIT_C61500 IAO_0000115 "A broad-spectrum, second generation, triazole compound with antifungal activity. Posaconazole strongly inhibits 14-alpha demethylase, a cytochrome P450-dependent enzyme. Inhibition of 14-alpha-demethylase prevents the conversion of lanosterol to ergosterol, an important component of the fungal cell wall. Inhibition of ergosterol synthesis changes the fungal cell membrane composition and integrity, alters membrane permeability and eventually leads to fungal cell lysis. Compared to other azole antifungals, posaconazole is a significantly more potent inhibitor of sterol 14-alpha demethylase." @default.
- NCIT_C61500 NCIT_NHC0 "C61500" @default.
- NCIT_C61500 NCIT_P106 "Organic Chemical" @default.
- NCIT_C61500 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61500 NCIT_P107 "Posaconazole" @default.
- NCIT_C61500 NCIT_P108 "Posaconazole" @default.
- NCIT_C61500 NCIT_P207 "C0936148" @default.
- NCIT_C61500 NCIT_P210 "171228-49-2" @default.
- NCIT_C61500 NCIT_P302 "Fungal Infection Prevention for Immunocompromised Host" @default.
- NCIT_C61500 NCIT_P319 "6TK1G07BHZ" @default.
- NCIT_C61500 NCIT_P322 "CTRP" @default.
- NCIT_C61500 NCIT_P322 "FDA" @default.
- NCIT_C61500 NCIT_P329 "361793" @default.
- NCIT_C61500 NCIT_P330 "361793" @default.
- NCIT_C61500 NCIT_P350 "C37H42F2N8O4" @default.
- NCIT_C61500 NCIT_P366 "Posaconazole" @default.
- NCIT_C61500 NCIT_P368 "CHEBI:64355" @default.
- NCIT_C61500 NCIT_P399 "361793" @default.
- NCIT_C61500 normalizedInformationContent "100" @default.
- NCIT_C61500 referenceCount "1" @default.
- NCIT_C61500 hasExactSynonym "Noxafil" @default.
- NCIT_C61500 hasExactSynonym "POSACONAZOLE" @default.
- NCIT_C61500 hasExactSynonym "Posaconazole" @default.
- NCIT_C61500 hasExactSynonym "SCH 56592" @default.
- NCIT_C61500 inSubset NCIT_C116977 @default.
- NCIT_C61500 inSubset NCIT_C116978 @default.
- NCIT_C61500 inSubset NCIT_C176424 @default.
- NCIT_C61500 inSubset NCIT_C63923 @default.
- NCIT_C61500 type Class @default.
- NCIT_C61500 isDefinedBy ncit.owl @default.
- NCIT_C61500 label "Posaconazole" @default.
- NCIT_C61500 subClassOf NCIT_C1908 @default.
- NCIT_C61500 subClassOf NCIT_C1909 @default.
- NCIT_C61500 subClassOf NCIT_C254 @default.
- NCIT_C61500 subClassOf NCIT_C514 @default.
- NCIT_C61500 subClassOf NCIT_C61500 @default.