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- NCIT_C61527 IAO_0000115 "A synthetic lipid-lowering agent. Atorvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. Atorvastatin also increases the number of LDL receptors on hepatic cell surfaces to enhance uptake and catabolism of LDL and reduces LDL production and the number of LDL particles. This agent lowers plasma cholesterol and lipoprotein levels and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. (NCI04)" @default.
- NCIT_C61527 NCIT_A5 NCIT_C28837 @default.
- NCIT_C61527 NCIT_A5 NCIT_C78676 @default.
- NCIT_C61527 NCIT_NHC0 "C61527" @default.
- NCIT_C61527 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61527 NCIT_P108 "Atorvastatin" @default.
- NCIT_C61527 NCIT_P207 "C0286651" @default.
- NCIT_C61527 NCIT_P210 "134523-00-5" @default.
- NCIT_C61527 NCIT_P319 "A0JWA85V8F" @default.
- NCIT_C61527 NCIT_P322 "FDA" @default.
- NCIT_C61527 NCIT_P325 "The active ingredient in a drug used to lower the amount of cholesterol in the blood and to prevent stroke, heart attack, and angina (chest pain). It is also being studied in the prevention and treatment of some types of cancer and other conditions. Atorvastatin blocks an enzyme that helps make cholesterol in the body. It also causes an increase in the breakdown of cholesterol. It is a type of HMG-CoA reductase inhibitor and a type of statin." @default.
- NCIT_C61527 NCIT_P350 "C33H35FN2O5" @default.
- NCIT_C61527 NCIT_P366 "Atorvastatin_Base" @default.
- NCIT_C61527 NCIT_P368 "CHEBI:39548" @default.
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- NCIT_C61527 NCIT_R66 NCIT_C40657 @default.
- NCIT_C61527 normalizedInformationContent "100" @default.
- NCIT_C61527 referenceCount "1" @default.
- NCIT_C61527 hasExactSynonym "(betaR,deltaR)-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid" @default.
- NCIT_C61527 hasExactSynonym "(betaR,deltaR)-2-(p-Fluorophenyl)-beta,delta-dihydroxy-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-pyrrole-1-heptanoic Acid" @default.
- NCIT_C61527 hasExactSynonym "ATORVASTATIN" @default.
- NCIT_C61527 hasExactSynonym "Atorvastatin" @default.
- NCIT_C61527 hasExactSynonym "atorvastatin" @default.
- NCIT_C61527 inSubset NCIT_C173381 @default.
- NCIT_C61527 inSubset NCIT_C173383 @default.
- NCIT_C61527 inSubset NCIT_C63923 @default.
- NCIT_C61527 type Class @default.
- NCIT_C61527 isDefinedBy ncit.owl @default.
- NCIT_C61527 label "Atorvastatin" @default.
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- NCIT_C61527 subClassOf NCIT_C78276 @default.