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- NCIT_C61564 IAO_0000115 "A bi-fluorinated derivative of the semi-synthetic vinca alkaloid vinorelbine with antitubulin, antineoplastic, and antiangiogenic activities. Vinflunine inhibits tubulin assembly without any stablization of assembled microtubules at concentrations comparable to those of other vinca alkaloids such as vincristine, vinblastine and vinorelbine; this effect on microtubule dynamics results in cell cycle arrest in mitosis and apoptosis. Compared to other vinca alkaloids, this agent binds weakly to the vinca-binding site, indicating that vinflunine may exhibit reduced neurotoxicity." @default.
- NCIT_C61564 NCIT_A32 NCIT_C1909 @default.
- NCIT_C61564 NCIT_A5 NCIT_C76266 @default.
- NCIT_C61564 NCIT_A7 NCIT_C129655 @default.
- NCIT_C61564 NCIT_NHC0 "C61564" @default.
- NCIT_C61564 NCIT_P106 "Organic Chemical" @default.
- NCIT_C61564 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61564 NCIT_P107 "Vinflunine" @default.
- NCIT_C61564 NCIT_P108 "Vinflunine" @default.
- NCIT_C61564 NCIT_P207 "C0672663" @default.
- NCIT_C61564 NCIT_P210 "162652-95-1" @default.
- NCIT_C61564 NCIT_P319 "5BF646324K" @default.
- NCIT_C61564 NCIT_P322 "CTRP" @default.
- NCIT_C61564 NCIT_P322 "FDA" @default.
- NCIT_C61564 NCIT_P322 "GDC" @default.
- NCIT_C61564 NCIT_P325 "A substance being studied in the treatment of bladder cancer, lung cancer, and other types of cancer." @default.
- NCIT_C61564 NCIT_P329 "419548" @default.
- NCIT_C61564 NCIT_P330 "419548" @default.
- NCIT_C61564 NCIT_P350 "C45H54F2N4O8" @default.
- NCIT_C61564 NCIT_P366 "Vinflunine" @default.
- NCIT_C61564 NCIT_P375 "Vinflunine" @default.
- NCIT_C61564 NCIT_P399 "419548" @default.
- NCIT_C61564 NCIT_R124 NCIT_C17828 @default.
- NCIT_C61564 NCIT_R124 NCIT_C20480 @default.
- NCIT_C61564 NCIT_R124 NCIT_C40795 @default.
- NCIT_C61564 NCIT_R124 NCIT_C40798 @default.
- NCIT_C61564 normalizedInformationContent "100" @default.
- NCIT_C61564 referenceCount "1" @default.
- NCIT_C61564 hasExactSynonym "4'-Deoxy-20',20'-difluoro-C'-norvincaleukoblastine" @default.
- NCIT_C61564 hasExactSynonym "VINFLUNINE" @default.
- NCIT_C61564 hasExactSynonym "Vinflunine" @default.
- NCIT_C61564 hasExactSynonym "vinflunine" @default.
- NCIT_C61564 inSubset NCIT_C116977 @default.
- NCIT_C61564 inSubset NCIT_C116978 @default.
- NCIT_C61564 inSubset NCIT_C128784 @default.
- NCIT_C61564 inSubset NCIT_C157711 @default.
- NCIT_C61564 inSubset NCIT_C157712 @default.
- NCIT_C61564 inSubset NCIT_C176424 @default.
- NCIT_C61564 inSubset NCIT_C177537 @default.
- NCIT_C61564 inSubset NCIT_C63923 @default.
- NCIT_C61564 type Class @default.
- NCIT_C61564 isDefinedBy ncit.owl @default.
- NCIT_C61564 label "Vinflunine" @default.
- NCIT_C61564 subClassOf NCIT_C186664 @default.
- NCIT_C61564 subClassOf NCIT_C1907 @default.
- NCIT_C61564 subClassOf NCIT_C1908 @default.
- NCIT_C61564 subClassOf NCIT_C1909 @default.
- NCIT_C61564 subClassOf NCIT_C1913 @default.
- NCIT_C61564 subClassOf NCIT_C1916 @default.
- NCIT_C61564 subClassOf NCIT_C1931 @default.
- NCIT_C61564 subClassOf NCIT_C221 @default.
- NCIT_C61564 subClassOf NCIT_C25974 @default.
- NCIT_C61564 subClassOf NCIT_C273 @default.
- NCIT_C61564 subClassOf NCIT_C274 @default.
- NCIT_C61564 subClassOf NCIT_C61564 @default.
- NCIT_C61564 subClassOf NCIT_C67422 @default.
- NCIT_C61564 subClassOf NCIT_C718 @default.
- NCIT_C61564 subClassOf NCIT_C932 @default.