Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C61565> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- NCIT_C61565 IAO_0000115 "The hydrochloride salt of bendamustine, a bifunctional mechlorethamine derivative with alkylator and antimetabolite activities. Bendamustine possesses three active moieties: an alkylating group; a benzimidazole ring, which may act as a purine analogue; and a butyric acid side chain. Although its exact mechanism of action is unknown this agent appears to act primarily as an alkylator. Bendamustine metabolites alkylate and crosslink macromolecules, resulting in DNA, RNA and protein synthesis inhibition, and, subsequently, apoptosis. Bendamustine may differ from other alkylators in that it may be more potent in activating p53-dependent stress pathways and inducing apoptosis; it may induce mitotic catastrophe; and it may activate a base excision DNA repair pathway rather than an alkyltransferase DNA repair mechanism. Accordingly, this agent may be more efficacious and less susceptible to drug resistance than other alkylators." @default.
- NCIT_C61565 NCIT_A32 NCIT_C1909 @default.
- NCIT_C61565 NCIT_A6 NCIT_C73261 @default.
- NCIT_C61565 NCIT_NHC0 "C61565" @default.
- NCIT_C61565 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C61565 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61565 NCIT_P107 "Bendamustine Hydrochloride" @default.
- NCIT_C61565 NCIT_P108 "Bendamustine Hydrochloride" @default.
- NCIT_C61565 NCIT_P175 "138783" @default.
- NCIT_C61565 NCIT_P207 "C0772139" @default.
- NCIT_C61565 NCIT_P210 "3543-75-7" @default.
- NCIT_C61565 NCIT_P302 "chronic lymphocytic leukemia" @default.
- NCIT_C61565 NCIT_P319 "981Y8SX18M" @default.
- NCIT_C61565 NCIT_P322 "CTRP" @default.
- NCIT_C61565 NCIT_P322 "FDA" @default.
- NCIT_C61565 NCIT_P322 "GDC" @default.
- NCIT_C61565 NCIT_P325 "A drug used to treat chronic lymphocytic leukemia (CLL). It is also used to treat slow-growing B-cell non-Hodgkin lymphoma (NHL) that has gotten worse within 6 months of treatment with other anticancer drugs.It is being studied in the treatment of other types of cancer. Bendamustine hydrochloride may damage the DNA in cancer cells and cause them to die. It is a type of alkylating agent and a type of antimetabolite." @default.
- NCIT_C61565 NCIT_P329 "350251" @default.
- NCIT_C61565 NCIT_P330 "350251" @default.
- NCIT_C61565 NCIT_P350 "C16H21Cl2N3O2.ClH" @default.
- NCIT_C61565 NCIT_P366 "Bendamustine_Hydrochloride" @default.
- NCIT_C61565 NCIT_P375 "Bendamustine Hydrochloride" @default.
- NCIT_C61565 NCIT_P399 "350251" @default.
- NCIT_C61565 normalizedInformationContent "82.536929774922015" @default.
- NCIT_C61565 referenceCount "14" @default.
- NCIT_C61565 hasExactSynonym "2-Benzimidazolinebutryric acid, 1-methyl-5-bis(2-chloroethyl)amino-, hydrochloride" @default.
- NCIT_C61565 hasExactSynonym "BENDAMUSTINE HYDROCHLORIDE" @default.
- NCIT_C61565 hasExactSynonym "Belrapzo" @default.
- NCIT_C61565 hasExactSynonym "Bendamustin Hydrochloride" @default.
- NCIT_C61565 hasExactSynonym "Bendamustine Hydrochloride" @default.
- NCIT_C61565 hasExactSynonym "Bendeka" @default.
- NCIT_C61565 hasExactSynonym "CEP-18083" @default.
- NCIT_C61565 hasExactSynonym "Cytostasan Hydrochloride" @default.
- NCIT_C61565 hasExactSynonym "Levact" @default.
- NCIT_C61565 hasExactSynonym "Ribomustin" @default.
- NCIT_C61565 hasExactSynonym "SyB L-0501" @default.
- NCIT_C61565 hasExactSynonym "Treakisym" @default.
- NCIT_C61565 hasExactSynonym "Treanda" @default.
- NCIT_C61565 hasExactSynonym "bendamustine hydrochloride" @default.
- NCIT_C61565 inSubset NCIT_C116977 @default.
- NCIT_C61565 inSubset NCIT_C116978 @default.
- NCIT_C61565 inSubset NCIT_C128784 @default.
- NCIT_C61565 inSubset NCIT_C157711 @default.
- NCIT_C61565 inSubset NCIT_C157712 @default.
- NCIT_C61565 inSubset NCIT_C176424 @default.
- NCIT_C61565 inSubset NCIT_C177537 @default.
- NCIT_C61565 inSubset NCIT_C63923 @default.
- NCIT_C61565 type Class @default.
- NCIT_C61565 isDefinedBy ncit.owl @default.
- NCIT_C61565 label "Bendamustine Hydrochloride" @default.
- NCIT_C61565 subClassOf NCIT_C1590 @default.
- NCIT_C61565 subClassOf NCIT_C186664 @default.
- NCIT_C61565 subClassOf NCIT_C1908 @default.
- NCIT_C61565 subClassOf NCIT_C1909 @default.
- NCIT_C61565 subClassOf NCIT_C2114 @default.
- NCIT_C61565 subClassOf NCIT_C274 @default.
- NCIT_C61565 subClassOf NCIT_C2842 @default.
- NCIT_C61565 subClassOf NCIT_C61565 @default.
- NCIT_C61565 subClassOf NCIT_C697 @default.