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- NCIT_C61571 IAO_0000115 "A temperature-sensitive liposomal formulation of the anthracycline antibiotic doxorubicin with potential antineoplastic activity. Upon intravenous administration, circulating thermosensitive liposomes are activated locally by increasing the tumor temperature to 40-41 degrees Celsius using an external heat source. The elevated temperature causes compositional changes in the liposomes, creating openings that allow for the release of encapsulated doxorubicin. Compared to non-thermosensitive liposomes, lyso-thermosensitive liposomes deliver higher concentrations of a cytotoxic agent to a heat-treated tumor site while sparing normal tissues unexposed to heat treatment." @default.
- NCIT_C61571 NCIT_A32 NCIT_C1909 @default.
- NCIT_C61571 NCIT_A7 NCIT_C18434 @default.
- NCIT_C61571 NCIT_NHC0 "C61571" @default.
- NCIT_C61571 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61571 NCIT_P107 "Lyso-Thermosensitive Liposome Doxorubicin" @default.
- NCIT_C61571 NCIT_P108 "Lyso-Thermosensitive Liposome Doxorubicin" @default.
- NCIT_C61571 NCIT_P207 "C1831903" @default.
- NCIT_C61571 NCIT_P322 "CTRP" @default.
- NCIT_C61571 NCIT_P322 "GDC" @default.
- NCIT_C61571 NCIT_P329 "491935" @default.
- NCIT_C61571 NCIT_P330 "491935" @default.
- NCIT_C61571 NCIT_P366 "Lyso-Thermosensitive_Liposome_Doxorubicin" @default.
- NCIT_C61571 NCIT_P375 "Lyso-Thermosensitive Liposome Doxorubicin" @default.
- NCIT_C61571 NCIT_P399 "491935" @default.
- NCIT_C61571 normalizedInformationContent "100" @default.
- NCIT_C61571 referenceCount "1" @default.
- NCIT_C61571 hasExactSynonym "Heat-Activated Liposomal Doxorubicin Hydrochloride" @default.
- NCIT_C61571 hasExactSynonym "Lyso-Thermosensitive Liposome Doxorubicin" @default.
- NCIT_C61571 hasExactSynonym "Temperature Sensitive Liposome Encapsulated Doxorubicin" @default.
- NCIT_C61571 hasExactSynonym "ThermoDox" @default.
- NCIT_C61571 inSubset NCIT_C116977 @default.
- NCIT_C61571 inSubset NCIT_C116978 @default.
- NCIT_C61571 inSubset NCIT_C128784 @default.
- NCIT_C61571 inSubset NCIT_C157711 @default.
- NCIT_C61571 inSubset NCIT_C157712 @default.
- NCIT_C61571 inSubset NCIT_C176424 @default.
- NCIT_C61571 inSubset NCIT_C177537 @default.
- NCIT_C61571 type Class @default.
- NCIT_C61571 isDefinedBy ncit.owl @default.
- NCIT_C61571 label "Lyso-Thermosensitive Liposome Doxorubicin" @default.
- NCIT_C61571 subClassOf NCIT_C129824 @default.
- NCIT_C61571 subClassOf NCIT_C129825 @default.
- NCIT_C61571 subClassOf NCIT_C1594 @default.
- NCIT_C61571 subClassOf NCIT_C1748 @default.
- NCIT_C61571 subClassOf NCIT_C186664 @default.
- NCIT_C61571 subClassOf NCIT_C1908 @default.
- NCIT_C61571 subClassOf NCIT_C1909 @default.
- NCIT_C61571 subClassOf NCIT_C1968 @default.
- NCIT_C61571 subClassOf NCIT_C2115 @default.
- NCIT_C61571 subClassOf NCIT_C2161 @default.
- NCIT_C61571 subClassOf NCIT_C2189 @default.
- NCIT_C61571 subClassOf NCIT_C259 @default.
- NCIT_C61571 subClassOf NCIT_C274 @default.
- NCIT_C61571 subClassOf NCIT_C2842 @default.
- NCIT_C61571 subClassOf NCIT_C471 @default.
- NCIT_C61571 subClassOf NCIT_C61571 @default.
- NCIT_C61571 subClassOf NCIT_C67502 @default.