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- NCIT_C61587 IAO_0000115 "A small-molecule 3-aminopyrazole derivative with potential antineoplastic activity. Danusertib binds to and inhibits the Aurora kinases, which may result in cell growth arrest and apoptosis in tumor cells in which Aurora kinases are overexpressed. This agent may preferentially bind to and inhibit Aurora B kinase. Aurora kinases, a family of serine-threonine kinases, are important regulators of cellular proliferation and division." @default.
- NCIT_C61587 NCIT_A32 NCIT_C1909 @default.
- NCIT_C61587 NCIT_NHC0 "C61587" @default.
- NCIT_C61587 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61587 NCIT_P107 "Danusertib" @default.
- NCIT_C61587 NCIT_P108 "Danusertib" @default.
- NCIT_C61587 NCIT_P207 "C2700603" @default.
- NCIT_C61587 NCIT_P210 "827318-97-8" @default.
- NCIT_C61587 NCIT_P319 "M3X659D0FY" @default.
- NCIT_C61587 NCIT_P322 "CTRP" @default.
- NCIT_C61587 NCIT_P322 "FDA" @default.
- NCIT_C61587 NCIT_P322 "GDC" @default.
- NCIT_C61587 NCIT_P325 "A substance being studied in the treatment of chronic myelogenous leukemia. PHA-739358 may stop tumor growth by blocking certain enzymes needed for cancer cells to divide and causing them to die. It is a type of kinase inhibitor." @default.
- NCIT_C61587 NCIT_P329 "489092" @default.
- NCIT_C61587 NCIT_P330 "489092" @default.
- NCIT_C61587 NCIT_P350 "C26H30N6O3" @default.
- NCIT_C61587 NCIT_P366 "PHA-739358" @default.
- NCIT_C61587 NCIT_P375 "Danusertib" @default.
- NCIT_C61587 NCIT_P399 "489092" @default.
- NCIT_C61587 NCIT_R146 NCIT_C16554 @default.
- NCIT_C61587 NCIT_R146 NCIT_C16984 @default.
- NCIT_C61587 NCIT_R146 NCIT_C17018 @default.
- NCIT_C61587 NCIT_R146 NCIT_C17021 @default.
- NCIT_C61587 NCIT_R146 NCIT_C17210 @default.
- NCIT_C61587 NCIT_R146 NCIT_C17325 @default.
- NCIT_C61587 NCIT_R146 NCIT_C20027 @default.
- NCIT_C61587 NCIT_R146 NCIT_C26548 @default.
- NCIT_C61587 NCIT_R146 NCIT_C30006 @default.
- NCIT_C61587 normalizedInformationContent "100" @default.
- NCIT_C61587 referenceCount "1" @default.
- NCIT_C61587 hasExactSynonym "Benzamide, 4-(4-methyl-1-piperazinyl)-N-(1,4,5,6-tetrahydro-5-((2R)- methoxyphenylacetyl)pyrrolo(3,4-c)pyrazol-3-yl)-" @default.
- NCIT_C61587 hasExactSynonym "DANUSERTIB" @default.
- NCIT_C61587 hasExactSynonym "Danusertib" @default.
- NCIT_C61587 hasExactSynonym "PHA-739358" @default.
- NCIT_C61587 inSubset NCIT_C116977 @default.
- NCIT_C61587 inSubset NCIT_C116978 @default.
- NCIT_C61587 inSubset NCIT_C128784 @default.
- NCIT_C61587 inSubset NCIT_C157711 @default.
- NCIT_C61587 inSubset NCIT_C157712 @default.
- NCIT_C61587 inSubset NCIT_C176424 @default.
- NCIT_C61587 inSubset NCIT_C177537 @default.
- NCIT_C61587 inSubset NCIT_C63923 @default.
- NCIT_C61587 type Class @default.
- NCIT_C61587 isDefinedBy ncit.owl @default.
- NCIT_C61587 label "Danusertib" @default.
- NCIT_C61587 subClassOf NCIT_C129824 @default.
- NCIT_C61587 subClassOf NCIT_C129825 @default.
- NCIT_C61587 subClassOf NCIT_C1404 @default.
- NCIT_C61587 subClassOf NCIT_C1908 @default.
- NCIT_C61587 subClassOf NCIT_C1909 @default.
- NCIT_C61587 subClassOf NCIT_C2189 @default.
- NCIT_C61587 subClassOf NCIT_C274 @default.
- NCIT_C61587 subClassOf NCIT_C471 @default.
- NCIT_C61587 subClassOf NCIT_C61074 @default.
- NCIT_C61587 subClassOf NCIT_C61587 @default.
- NCIT_C61587 subClassOf NCIT_C62556 @default.