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- NCIT_C61590 IAO_0000115 "A non-toxic, small-molecule, hypoxia-activated, 3,5-dinitrobenzamide nitrogen mustard pre-prodrug with potential antitumor activity. Upon intravenous administration, PR-104 is converted by systemic phosphatases to the alcohol intermediate PR-104A, which is reduced to form the active DNA-crosslinking mustard species hydroxylamine PR-104H intracellularly under hypoxic conditions. PR-104H specifically crosslinks hypoxic tumor cell DNA, resulting in the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis in susceptible hypoxic tumor cell populations while sparing normoxic tissues." @default.
- NCIT_C61590 NCIT_A32 NCIT_C1909 @default.
- NCIT_C61590 NCIT_A7 NCIT_C449 @default.
- NCIT_C61590 NCIT_NHC0 "C61590" @default.
- NCIT_C61590 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61590 NCIT_P107 "PR-104" @default.
- NCIT_C61590 NCIT_P108 "Nitrogen Mustard Prodrug PR-104" @default.
- NCIT_C61590 NCIT_P207 "C1831907" @default.
- NCIT_C61590 NCIT_P210 "851627-62-8" @default.
- NCIT_C61590 NCIT_P319 "V16D2ZT7DT" @default.
- NCIT_C61590 NCIT_P322 "CTRP" @default.
- NCIT_C61590 NCIT_P322 "FDA" @default.
- NCIT_C61590 NCIT_P322 "GDC" @default.
- NCIT_C61590 NCIT_P325 "A substance being studied in the treatment of cancer. PR-104 becomes active when cancer cells don't receive enough oxygen. It may kill cancer cells by damaging their DNA." @default.
- NCIT_C61590 NCIT_P329 "492222" @default.
- NCIT_C61590 NCIT_P330 "492222" @default.
- NCIT_C61590 NCIT_P366 "PR-104" @default.
- NCIT_C61590 NCIT_P375 "Nitrogen Mustard Prodrug PR-104" @default.
- NCIT_C61590 NCIT_P399 "492222" @default.
- NCIT_C61590 normalizedInformationContent "100" @default.
- NCIT_C61590 referenceCount "1" @default.
- NCIT_C61590 hasExactSynonym "((2-Bromoethyl)-2,4-dinitro-6-(((2-(phosphonooxy)ethyl)amino)-carbonyl)anilino)ethyl Methanesulphonate" @default.
- NCIT_C61590 hasExactSynonym "Nitrogen Mustard Prodrug PR-104" @default.
- NCIT_C61590 hasExactSynonym "PR-104" @default.
- NCIT_C61590 hasExactSynonym "PR104" @default.
- NCIT_C61590 inSubset NCIT_C116977 @default.
- NCIT_C61590 inSubset NCIT_C116978 @default.
- NCIT_C61590 inSubset NCIT_C128784 @default.
- NCIT_C61590 inSubset NCIT_C157711 @default.
- NCIT_C61590 inSubset NCIT_C157712 @default.
- NCIT_C61590 inSubset NCIT_C176424 @default.
- NCIT_C61590 inSubset NCIT_C177537 @default.
- NCIT_C61590 inSubset NCIT_C63923 @default.
- NCIT_C61590 type Class @default.
- NCIT_C61590 isDefinedBy ncit.owl @default.
- NCIT_C61590 label "Nitrogen Mustard Prodrug PR-104" @default.
- NCIT_C61590 subClassOf NCIT_C1590 @default.
- NCIT_C61590 subClassOf NCIT_C186664 @default.
- NCIT_C61590 subClassOf NCIT_C1908 @default.
- NCIT_C61590 subClassOf NCIT_C1909 @default.
- NCIT_C61590 subClassOf NCIT_C2114 @default.
- NCIT_C61590 subClassOf NCIT_C274 @default.
- NCIT_C61590 subClassOf NCIT_C2842 @default.
- NCIT_C61590 subClassOf NCIT_C61590 @default.
- NCIT_C61590 subClassOf NCIT_C697 @default.