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- NCIT_C61625 IAO_0000115 "A second generation bisphosphonate and synthetic analog of pyrophosphate with anti-bone-resorption activity. Alendronic acid binds to and inhibits the activity of farnesyl pyrophosphate synthetase, an enzyme involved in terpenoid biosynthesis. Inhibition of this enzyme prevents the biosynthesis of isoprenoid lipids, donor substrates of farnesylation and geranylgeranylation during the post-translational modification of small GTPase signalling proteins, which are important in the process of osteoclast turnover. As a result, bone resorption and turnover are reduced." @default.
- NCIT_C61625 NCIT_A5 NCIT_C973 @default.
- NCIT_C61625 NCIT_NHC0 "C61625" @default.
- NCIT_C61625 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61625 NCIT_P108 "Alendronic Acid" @default.
- NCIT_C61625 NCIT_P207 "C0771311" @default.
- NCIT_C61625 NCIT_P210 "66376-36-1" @default.
- NCIT_C61625 NCIT_P319 "X1J18R4W8P" @default.
- NCIT_C61625 NCIT_P322 "FDA" @default.
- NCIT_C61625 NCIT_P350 "C4H13NO7P2" @default.
- NCIT_C61625 NCIT_P366 "Alendronic_Acid" @default.
- NCIT_C61625 NCIT_P368 "CHEBI:2567" @default.
- NCIT_C61625 normalizedInformationContent "100" @default.
- NCIT_C61625 referenceCount "1" @default.
- NCIT_C61625 hasExactSynonym "(4-Amino-1-hydroxybutylidene)bisphosphonic Acid" @default.
- NCIT_C61625 hasExactSynonym "ALENDRONIC ACID" @default.
- NCIT_C61625 hasExactSynonym "Alendronate" @default.
- NCIT_C61625 hasExactSynonym "Alendronic Acid" @default.
- NCIT_C61625 inSubset NCIT_C63923 @default.
- NCIT_C61625 type Class @default.
- NCIT_C61625 isDefinedBy ncit.owl @default.
- NCIT_C61625 label "Alendronic Acid" @default.
- NCIT_C61625 subClassOf NCIT_C1908 @default.
- NCIT_C61625 subClassOf NCIT_C1909 @default.
- NCIT_C61625 subClassOf NCIT_C1913 @default.
- NCIT_C61625 subClassOf NCIT_C443 @default.
- NCIT_C61625 subClassOf NCIT_C61625 @default.
- NCIT_C61625 subClassOf NCIT_C67439 @default.
- NCIT_C61625 subClassOf NCIT_C718 @default.
- NCIT_C61625 subClassOf NCIT_C78281 @default.