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- NCIT_C61635 IAO_0000115 "A synthetic dihydropyridine and a calcium channel blocker with antihypertensive and antianginal properties. Amlodipine inhibits the influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells, thereby preventing vascular and myocardial contraction. This results in a dilatation of the main coronary and systemic arteries, decreased myocardial contractility, increased blood flow and oxygen delivery to the myocardial tissue, and decreased total peripheral resistance. This agent may also modulate multi-drug resistance (MDR) activity through inhibition of the p-glycoprotein efflux pump." @default.
- NCIT_C61635 NCIT_A5 NCIT_C28820 @default.
- NCIT_C61635 NCIT_A5 NCIT_C65230 @default.
- NCIT_C61635 NCIT_NHC0 "C61635" @default.
- NCIT_C61635 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61635 NCIT_P108 "Amlodipine" @default.
- NCIT_C61635 NCIT_P207 "C0051696" @default.
- NCIT_C61635 NCIT_P210 "88150-42-9" @default.
- NCIT_C61635 NCIT_P319 "1J444QC288" @default.
- NCIT_C61635 NCIT_P322 "FDA" @default.
- NCIT_C61635 NCIT_P350 "C20H25ClN2O5" @default.
- NCIT_C61635 NCIT_P366 "Amlodipine" @default.
- NCIT_C61635 NCIT_P368 "CHEBI:2668" @default.
- NCIT_C61635 normalizedInformationContent "100" @default.
- NCIT_C61635 referenceCount "1" @default.
- NCIT_C61635 hasExactSynonym "AMLODIPINE" @default.
- NCIT_C61635 hasExactSynonym "Amlodipine" @default.
- NCIT_C61635 inSubset NCIT_C63923 @default.
- NCIT_C61635 type Class @default.
- NCIT_C61635 isDefinedBy ncit.owl @default.
- NCIT_C61635 label "Amlodipine" @default.
- NCIT_C61635 subClassOf NCIT_C1908 @default.
- NCIT_C61635 subClassOf NCIT_C1909 @default.
- NCIT_C61635 subClassOf NCIT_C270 @default.
- NCIT_C61635 subClassOf NCIT_C333 @default.
- NCIT_C61635 subClassOf NCIT_C61635 @default.
- NCIT_C61635 subClassOf NCIT_C78274 @default.
- NCIT_C61635 subClassOf NCIT_C93038 @default.