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- NCIT_C61637 IAO_0000115 "A labdane diterpenoid that is produced by the Andrographis paniculata plant, which has a broad range of therapeutic applications including anti-inflammatory and anti-platelet aggregation activities and potential antineoplastic properties. Since andrographolide has multiple therapeutic activities there are several proposed mechanisms of action for this agent. The anti-inflammatory effects of this agent appear to be related to the inhibition of nitric oxide (NO) production by macrophages. This agent may activate the NO/cyclic GMP pathway and inhibit both the phospholipase C gamma 2 (PLC gamma2)/protein kinase C (PKC) and PI3K/AKT-MAPK signaling pathways in activated platelets to inhibit platelet aggregation. In activated platelets, these three signaling pathways are downstream of integrin activation mediated by collagen binding and influence the association of fibrinogen with its receptors. Additionally, andrographolide may exert its anti-cancer activity through the induction of cell cycle arrest at G0/G1 phase and the stimulation of lymphocyte proliferation and activation. These processes could result in decreased proliferation of and increased immunocytotoxicity against tumor cells." @default.
- NCIT_C61637 NCIT_A32 NCIT_C1909 @default.
- NCIT_C61637 NCIT_NHC0 "C61637" @default.
- NCIT_C61637 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61637 NCIT_P108 "Andrographolide" @default.
- NCIT_C61637 NCIT_P207 "C0051821" @default.
- NCIT_C61637 NCIT_P210 "5508-58-7" @default.
- NCIT_C61637 NCIT_P319 "410105JHGR" @default.
- NCIT_C61637 NCIT_P322 "FDA" @default.
- NCIT_C61637 NCIT_P322 "GDC" @default.
- NCIT_C61637 NCIT_P329 "755596" @default.
- NCIT_C61637 NCIT_P330 "755596" @default.
- NCIT_C61637 NCIT_P350 "C20H30O5" @default.
- NCIT_C61637 NCIT_P366 "Andrographolide" @default.
- NCIT_C61637 NCIT_P368 "CHEBI:65408" @default.
- NCIT_C61637 NCIT_P375 "Andrographolide" @default.
- NCIT_C61637 NCIT_P399 "755596" @default.
- NCIT_C61637 normalizedInformationContent "100" @default.
- NCIT_C61637 referenceCount "1" @default.
- NCIT_C61637 hasExactSynonym "(1R-(1-alpha(E(S)),4a-beta,5alpha,6alpha,8a-alpha))-3-(2-(decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl)ethylidene)dihydro-4-hydroxy-2(3H)-furanone" @default.
- NCIT_C61637 hasExactSynonym "(3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]-4-hydroxyoxolan-2-one" @default.
- NCIT_C61637 hasExactSynonym "(3E,4S)-4-hydroxy-3-{2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidenedecahydronaphthalen-1-yl]ethylidene}dihydrofuran-2(3H)-one" @default.
- NCIT_C61637 hasExactSynonym "2(3H)-Furanone, 3-(2-(decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl)ethylidene)dihydro-4-hydroxy-, (1R-(1-alpha(E(S*)),4a-beta,5-alpha,6-alpha,8a-alpha))-" @default.
- NCIT_C61637 hasExactSynonym "3-(2-(decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenenaphthyl)ethylidene)dihydro-4-hydroxyfuran-2(3H)-one" @default.
- NCIT_C61637 hasExactSynonym "3alpha,14,15,18-tetrahydroxy-5b,9bH,10a-labda-8(20),12-dien-16-oic acid gamma-Lactone" @default.
- NCIT_C61637 hasExactSynonym "ANDROGRAPHOLIDE" @default.
- NCIT_C61637 hasExactSynonym "Andrographis" @default.
- NCIT_C61637 hasExactSynonym "Andrographolide" @default.
- NCIT_C61637 inSubset NCIT_C128784 @default.
- NCIT_C61637 inSubset NCIT_C157711 @default.
- NCIT_C61637 inSubset NCIT_C157712 @default.
- NCIT_C61637 inSubset NCIT_C176424 @default.
- NCIT_C61637 inSubset NCIT_C177537 @default.
- NCIT_C61637 inSubset NCIT_C63923 @default.
- NCIT_C61637 type Class @default.
- NCIT_C61637 isDefinedBy ncit.owl @default.
- NCIT_C61637 label "Andrographolide" @default.
- NCIT_C61637 subClassOf NCIT_C1327 @default.
- NCIT_C61637 subClassOf NCIT_C1908 @default.
- NCIT_C61637 subClassOf NCIT_C1909 @default.
- NCIT_C61637 subClassOf NCIT_C61637 @default.
- NCIT_C61637 subClassOf NCIT_C78275 @default.