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- NCIT_C61671 IAO_0000115 "A 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. This agent may also interfere with the biosynthesis of nucleic acids. Chloroquine's potential chemosensitizing and radiosensitizing activities in cancer may be related to its inhibition of autophagy, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species (ROS) related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation." @default.
- NCIT_C61671 NCIT_A32 NCIT_C1909 @default.
- NCIT_C61671 NCIT_A5 NCIT_C47445 @default.
- NCIT_C61671 NCIT_A5 NCIT_C65318 @default.
- NCIT_C61671 NCIT_A5 NCIT_C78058 @default.
- NCIT_C61671 NCIT_NHC0 "C61671" @default.
- NCIT_C61671 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61671 NCIT_P107 "Chloroquine" @default.
- NCIT_C61671 NCIT_P108 "Chloroquine" @default.
- NCIT_C61671 NCIT_P207 "C0008269" @default.
- NCIT_C61671 NCIT_P210 "54-05-7" @default.
- NCIT_C61671 NCIT_P319 "886U3H6UFF" @default.
- NCIT_C61671 NCIT_P322 "CTRP" @default.
- NCIT_C61671 NCIT_P322 "FDA" @default.
- NCIT_C61671 NCIT_P322 "GDC" @default.
- NCIT_C61671 NCIT_P329 "654729" @default.
- NCIT_C61671 NCIT_P330 "654729" @default.
- NCIT_C61671 NCIT_P350 "C18H26ClN3" @default.
- NCIT_C61671 NCIT_P366 "Chloroquine" @default.
- NCIT_C61671 NCIT_P368 "CHEBI:3638" @default.
- NCIT_C61671 NCIT_P375 "Chloroquine" @default.
- NCIT_C61671 NCIT_P399 "654729" @default.
- NCIT_C61671 normalizedInformationContent "100" @default.
- NCIT_C61671 referenceCount "1" @default.
- NCIT_C61671 hasExactSynonym "CHLOROQUINE" @default.
- NCIT_C61671 hasExactSynonym "Chloroquine" @default.
- NCIT_C61671 inSubset NCIT_C116977 @default.
- NCIT_C61671 inSubset NCIT_C116978 @default.
- NCIT_C61671 inSubset NCIT_C128784 @default.
- NCIT_C61671 inSubset NCIT_C157711 @default.
- NCIT_C61671 inSubset NCIT_C157712 @default.
- NCIT_C61671 inSubset NCIT_C173381 @default.
- NCIT_C61671 inSubset NCIT_C173383 @default.
- NCIT_C61671 inSubset NCIT_C176424 @default.
- NCIT_C61671 inSubset NCIT_C177537 @default.
- NCIT_C61671 inSubset NCIT_C63923 @default.
- NCIT_C61671 type Class @default.
- NCIT_C61671 isDefinedBy ncit.owl @default.
- NCIT_C61671 label "Chloroquine" @default.
- NCIT_C61671 subClassOf NCIT_C1908 @default.
- NCIT_C61671 subClassOf NCIT_C1909 @default.
- NCIT_C61671 subClassOf NCIT_C254 @default.
- NCIT_C61671 subClassOf NCIT_C271 @default.
- NCIT_C61671 subClassOf NCIT_C276 @default.
- NCIT_C61671 subClassOf NCIT_C277 @default.
- NCIT_C61671 subClassOf NCIT_C61671 @default.