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- NCIT_C61685 IAO_0000115 "A first-generation bisphosphonate with anti-resorptive and anti-hypercalcemic activities. Clodronic acid adsorbs onto the surface of the hydroxyapatite crystals in bone matrix. Although the exact mechanism through which clodronic acid exerts its cytotoxic effect on osteoclasts has yet to be fully elucidated, this agent is metabolized intracellularly to a toxic beta-gamma-methylene analog of adenosine triphosphate (ATP), AppCCl2p. The ATP analog AppCCl2p competitively inhibits ADP/ATP translocase, thereby interfering with mitochondrial membrane potential and cellular energy metabolism. This may cause osteoclast apoptosis and, eventually, inhibiting osteoclast-mediated bone resorption." @default.
- NCIT_C61685 NCIT_A32 NCIT_C1909 @default.
- NCIT_C61685 NCIT_A5 NCIT_C1418 @default.
- NCIT_C61685 NCIT_NHC0 "C61685" @default.
- NCIT_C61685 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61685 NCIT_P108 "Clodronic Acid" @default.
- NCIT_C61685 NCIT_P207 "C0012081" @default.
- NCIT_C61685 NCIT_P210 "10596-23-3" @default.
- NCIT_C61685 NCIT_P319 "0813BZ6866" @default.
- NCIT_C61685 NCIT_P322 "FDA" @default.
- NCIT_C61685 NCIT_P322 "GDC" @default.
- NCIT_C61685 NCIT_P350 "CH4Cl2O6P2" @default.
- NCIT_C61685 NCIT_P366 "Clodronic_Acid" @default.
- NCIT_C61685 NCIT_P368 "CHEBI:110423" @default.
- NCIT_C61685 NCIT_P375 "Clodronic Acid" @default.
- NCIT_C61685 normalizedInformationContent "100" @default.
- NCIT_C61685 referenceCount "1" @default.
- NCIT_C61685 hasExactSynonym "(Dichloromethylene)bisphosphonic Acid" @default.
- NCIT_C61685 hasExactSynonym "CLODRONIC ACID" @default.
- NCIT_C61685 hasExactSynonym "Clodronate" @default.
- NCIT_C61685 hasExactSynonym "Clodronic Acid" @default.
- NCIT_C61685 inSubset NCIT_C157711 @default.
- NCIT_C61685 inSubset NCIT_C157712 @default.
- NCIT_C61685 inSubset NCIT_C177537 @default.
- NCIT_C61685 inSubset NCIT_C63923 @default.
- NCIT_C61685 type Class @default.
- NCIT_C61685 isDefinedBy ncit.owl @default.
- NCIT_C61685 label "Clodronic Acid" @default.
- NCIT_C61685 subClassOf NCIT_C1908 @default.
- NCIT_C61685 subClassOf NCIT_C1909 @default.
- NCIT_C61685 subClassOf NCIT_C1913 @default.
- NCIT_C61685 subClassOf NCIT_C443 @default.
- NCIT_C61685 subClassOf NCIT_C61685 @default.
- NCIT_C61685 subClassOf NCIT_C67439 @default.
- NCIT_C61685 subClassOf NCIT_C718 @default.
- NCIT_C61685 subClassOf NCIT_C78281 @default.