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- NCIT_C61701 IAO_0000115 "A synthetic octapeptide, and an analogue of human hormone arginine vasopressin with antidiuretic and coagulant activities. Desmopressin binds to V2 receptors in renal collecting ducts which leads to exocytosis of von Willebrand factor (VWF) and tissue plasminogen activator (t-PA) from Weibel-Palade bodies, thereby increasing water resorption. This agent also increases nitric oxide (NO) production via activation of endothelial NO synthase, thereby induces afferent arteriolar vasodilation. Furthermore, desmopressin stimulates the release of factor VIII from endothelial cells mediated through V1a receptor, thereby promotes blood coagulation." @default.
- NCIT_C61701 NCIT_A5 NCIT_C47475 @default.
- NCIT_C61701 NCIT_NHC0 "C61701" @default.
- NCIT_C61701 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61701 NCIT_P108 "Desmopressin" @default.
- NCIT_C61701 NCIT_P207 "C0011701" @default.
- NCIT_C61701 NCIT_P210 "16679-58-6" @default.
- NCIT_C61701 NCIT_P319 "ENR1LLB0FP" @default.
- NCIT_C61701 NCIT_P322 "FDA" @default.
- NCIT_C61701 NCIT_P350 "C46H64N14O12S2" @default.
- NCIT_C61701 NCIT_P366 "Desmopressin" @default.
- NCIT_C61701 NCIT_P368 "CHEBI:4450" @default.
- NCIT_C61701 normalizedInformationContent "100" @default.
- NCIT_C61701 referenceCount "1" @default.
- NCIT_C61701 hasExactSynonym "1-Deamino-8-D-arginine Vasopressin" @default.
- NCIT_C61701 hasExactSynonym "DESMOPRESSIN" @default.
- NCIT_C61701 hasExactSynonym "Desmopressin" @default.
- NCIT_C61701 inSubset NCIT_C63923 @default.
- NCIT_C61701 type Class @default.
- NCIT_C61701 isDefinedBy ncit.owl @default.
- NCIT_C61701 label "Desmopressin" @default.
- NCIT_C61701 subClassOf NCIT_C147908 @default.
- NCIT_C61701 subClassOf NCIT_C1908 @default.
- NCIT_C61701 subClassOf NCIT_C1909 @default.
- NCIT_C61701 subClassOf NCIT_C548 @default.
- NCIT_C61701 subClassOf NCIT_C61701 @default.
- NCIT_C61701 subClassOf NCIT_C80212 @default.